尿激酶联合胸腔闭式引流对结核性胸腔积液的临床效果

Clinical Effect of Urokinase Combined with Closed Thoracic Drainage on Tuberculous Pleural Effusion

目的分析结核性胸腔积液患者中,应用尿激酶联合胸腔闭式引流的临床价值。方法选取该院2016年8月—2019年8月收治的60例结核性胸腔积液患者,根据随机数字表法将所有的患者等分为治疗组(n=30)和常规组(n=30)。将两组治疗后的蛋白量水平以及白细胞浓度、胸水吸收时间以及住院时间、胸膜厚度、治疗效果进行对比。结果治疗后,相比于常规组(50.23±5.22)g/L、(2.11±0.54)×10^9,治疗组的蛋白量水平(41.23±3.58)g/L以及白细胞浓度(1.23±0.41)×10^9明显低,差异有统计学意义(P<0.05);相比于常规组(11.23±2.11)、(16.55±2.20)d,治疗组的胸水吸收时间(8.44±1.02)d以及住院时间(12.63±1.89)d明显短,差异有统计学意义(P<0.05)。治疗1、3个月,相比于常规组(4.56±0.89)、(3.22±0.56)mm,治疗组胸膜厚度(3.11±0.58)、(1.36±0.49)mm明显薄,差异有统计学意义(P<0.05);较之常规组(73.33%),治疗组的治疗总有效率(93.33%)高,差异有统计学意义(χ^2=4.320,P<0.05)。结论应用胸腔闭式引流联合尿激酶干预,可以明显改善胸腔积液的黏稠度,降解纤维蛋白,缩短了积液的引流时间,促进了身体的康复。

Objective To analyze the clinical value of urokinase combined with closed pleural drainage in patients with tuberculous pleural effusion.Methods A total of 60 patients with tuberculous pleural effusion received in the hospital from August 2016 to August 2019 were selected,and all patients were equally divided into treatment group and routine group according to the random number table method.The protein level and white blood cell concentration,pleural fluid absorption time,hospitalization time,pleural thickness,and therapeutic effect of the two groups after treatment were compared.Results After treatment,compared with the conventional group(50.23±5.22)g/L and(2.11±0.54)×10^9,the protein level(41.23±3.58)g/L and white blood cell concentration(1.23±0.41)×10^9 of the treatment group were significantly lower,the difference was statistically significant(P<0.05);compared with the routine group(11.23±2.11)d,(16.55±2.20)d,the absorption time of pleural fluid(8.44±1.02)d and hospitalization time(12.63±1.89)d in the treatment group were significantly shorter,the difference was statistically significant(P<0.05).After 1 and 3 months of treatment,compared with the conventional group(4.56±0.89)mm and(3.22±0.56)mm,the pleural thickness(3.11±0.58)mm and(1.36±0.49)mm of the treatment group were significantly thinner,the difference was statistically significant(P<0.05);compared with the control group(73.33%),the total effective rate(93.33%)higher,the difference was statistically significant(χ^2=4.320,P<0.05).Conclusion The application of closed pleural drainage combined with urokinase intervention can significantly improve the viscosity of pleural effusion,degrade fibrin,shorten the drainage time of effusion,and promote physical recovery.