布地奈德、可必特雾化吸入治疗慢阻肺急性加重刍议

On the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary(AECOPD)by Nebulized Inhalation of Budesonide and Cobitone

目的探究布地奈德、可必特雾化吸入治疗慢阻肺急性加重期(AECOPD)患者临床疗效情况。方法以2017年2月—2019年10月为研究时段,方便选取其中就该院接受治疗的74例慢性阻塞急性加重期患者作为对象。基于数字表法随机均分成立参照及研究两组,每组37例。参照组采用吸氧、止咳化痰及抗感染等常规治疗;研究组则就常规治疗基础上给予布地奈德联合可必特雾化吸入治疗方法。对比分析两组临床疗效、治疗前后的动脉气血指标情况及不良反应发生率。结果两组治疗前3项动脉气血指标对比均差异无统计学意义(P>0.05);治疗后研究组3项指标相较于参照组均呈现显著优越性,差异有统计学意义(P<0.05);且该组治疗总有效率94.59%及不良反应发生率8.11%相较于参照组78.38%、27.03%均呈现显著优越性,差异有统计学意义(χ^2=4.163、4.573,P<0.05)。结论与常规治疗方式相比,应用布地奈德联合可必特雾化吸入治疗慢阻肺急性加重期患者疗效更为显著,能有效降低患者不良反应发生率,提高治疗效果,改善患者动脉气血情况,促进身体恢复。

Objective To explore the clinical efficacy of nebulized inhalation of budesonide and cobitone in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From February 2017 to October 2019 as the study period,convenient selection 74 patients with acute exacerbation of chronic obstruction who were treated in the hospital were selected as the subjects.Based on the number table method,the two groups were randomly divided into two groups,37 cases in each group.The reference group was given conventional treatments such as oxygen inhalation,relieving cough and phlegm,and anti-infection;the research group was given budesonide combined with cobitone atomized inhalation treatment on the basis of conventional treatment.The clinical efficacy,arterial qi and blood indicators before and after treatment and the incidence of adverse reactions were compared and analyzed between the two groups.Results There was no significant difference in the comparison of the 3 arterial qi and blood indexes between the two groups before treatment(P>0.05);after treatment,the 3 indexes of the study group showed significant advantages compared with the reference group,and the difference was statistically significant(P<0.05);Moreover,the total effective rate of treatment 94.59%and the incidence of adverse reactions 8.11%in this group were significantly superior to the reference group 78.38%and 27.03%,the difference was statistically significant(χ^2=4.163,4.573,P<0.05).Conclusion Compared with conventional treatments,the application of budesonide combined with Cobite aerosol inhalation to treat patients with acute exacerbation of chronic obstructive pulmonary disease has a more significant effect,which can effectively reduce the incidence of adverse reactions in patients,improve the treatment effect,and improve the arterial gas blood condition of patients,promote body recovery.