基于网络药理学分析解痉舒督汤治疗强直性脊柱炎的作用机制

Analysis of mechanism of Jiejing Shudu decoction in the treatment of ankylosing spondylitis based on network pharmacology

目的探讨解痉舒督汤治疗强直性脊柱炎(AS)的作用机制,为进一步研究提供思路。方法采用中药系统药理学技术平台(TCMSP)筛选出解痉舒督汤所含药物的化学成分及其靶基因,从GeneCards、OMIM、DisGenet、Uniprot数据库中筛选AS的相关基因,并运用DAVID数据库对解痉舒督汤与AS共有基因进行分析。结果解痉舒督汤与AS的共同作用基因共72个。GO-BP功能分析结果显示,共同基因主要作用于炎症反应及免疫应答等方面。KEGG-MAP机制图显示,解痉舒督汤治疗AS的靶点分布主要与炎症相关的白细胞募集、炎症因子、细胞黏附及细胞外基质重塑密切相关。结论解痉舒督汤治疗AS的作用机制与通过多靶点、多通路调节炎症反应、免疫应答等方面有关。

Objective To explore the mechanism of Jiejing Shudu decoction in the treatment of ankylosing spondylitis(AS)so to provide ideas for further research.Methods The chemical components and target genes of Jiejing Shudu decoction were screened by traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP).Genes related to AS were screened from GeneCards,OMIM,DisGenet and Uniprot databases,and the common genes of Jiejing Shudu decoction and AS were analyzed by DAVID database.Results There were 72 joint action genes of Jiejing Shudu decoction and AS.The results of GO-BP functional analysis showed that the common genes were mainly involved in inflammatory response,immune response and the other aspect.KEGG-MAP mechanism diagram showed that the target distribution of Jiejing Shudu decoction in the treatment of AS is closely related to inflammation related leukocyte recruitment,inflammatory factors,cell adhesion and remodeling of extracellular matrix.Conclusion The mechanism of Jiejing Shudu decoction in the treatment of AS is related to the regulation of inflammatory response and immune response through multiple targets and pathways.