汉防己甲素联合川芎嗪注射液治疗尘肺病合并肺动脉高压的临床效果及对血清H2S、ET-1水平的影响

Clinical effect of tetrandrine combined with ligustrazine injection in the treatment of pneumoconiosis complicated with pulmonary hypertension and its influence on levels of serum H2S and ET-1

目的探究汉防己甲素(TET)联合川芎嗪注射液治疗尘肺病合并肺动脉高压(PAH)的临床效果及对血清H2S、ET-1水平的影响。方法选择我院收治的252例尘肺病合并PAH患者,采用随机数字表法将其分为对照组(126例,TET)和研究组(126例,TET+川芎嗪注射液)。比较两组的治疗效果。结果研究组的治疗效果明显优于对照组(P<0.05)。治疗后,两组气促、胸痛、咳嗽咳痰评分、PAPs及ET-1水平均降低,SaO2及H2S水平均升高,且研究组明显优于对照组(P<0.05)。结论TET联合川芎嗪注射液治疗尘肺病合并PAH的临床效果显著,可有效促进内皮功能恢复,改善机体缺氧状态。

Objective To investigate the clinical effect of tetrandrine(TET)combined with ligustrazine injection in the treatment of pneumoconiosis complicated with pulmonary hypertension(PAH)and its influence on levels of serum H2S and ET-1.Methods A total of 252 patients pneumoconiosis complicated with PAH treated in our hospital were selected and divided into control group(126 cases,TET)and study group(126 cases,TET+ligustrazine injection)by random number table method.The therapeutic effects of the two groups were compared.Results The therapeutic effect of the study group was significantly better than that of the control group(P<0.05).After treatment,the scores of shortness of breath,chest pain,cough and sputum,PAPs and ET-1 levels in both groups decreased,SaO2 and H2S levels increased,and those in the study group were significantly better than the control group(P<0.05).Conclusion TET combined with ligustrazine injection in the treatment of pneumoconiosis complicated with PAH has a significant clinical effect,which can effectively promote the recovery of endothelial function and improve the body's hypoxia state.