低分子肝素治疗胎儿生长受限的效果及对围生儿结局的影响

Effect of low molecular weight heparin in the treatment of fetal growth restriction and its influence on perinatal outcome

目的探索低分子肝素治疗胎儿生长受限的效果及对围生儿结局的影响。方法选择120例胎儿生长受限的孕妇为试验对象,根据单双号随机化法将其分为对照组和观察组,各60例。对照组采用常规治疗,观察组采用低分子肝素治疗。比较两组的收缩期血液流速高值/舒张晚期血液流速高值(S/D)、阻力指数(RI)、搏动指数(PI)、胎儿每周生长发育情况(双顶径、腹围、头围、宫高)、胎儿的生物物理评分、治疗效果及围生儿结局。结果治疗后,观察组S/D、RI、PI均低于对照组(P<0.05)。观察组每周双顶径、腹围、头围、宫高增长情况均优于对照组(P<0.05)。治疗后,观察组胎儿的生物物理评分高于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。观察组极低体重儿、早产儿、新生儿窒息、胎儿窘迫发生率均低于对照组(P<0.05)。结论运用低分子肝素治疗胎儿生长受限的效果显著,有利于改善围生儿结局,促使胎儿健康生长、发育。

Objective To explore the effect of low molecular weight heparin in the treatment of fetal growth restriction and its influence on perinatal outcome.Methods A total of 120 pregnant women with fetal growth restriction were selected as the test objects.The pregnant women were randomly divided into control group and observation group by single and double numbers randomized method,with 60 cases in each group.The control group was given conventional treatment,and the observation group was treated with low molecular weight heparin.The high blood flow rate during systole/high blood flow rate during late diastole(S/D),resistance index(RI),pulsatility index(PI),fetal weekly growth and development(double top diameter,abdominal circumference,head circumference,uterine height),fetal biophysical score,treatment effect and perinatal outcome were compared between the two groups.Results After treatment,S/D,RI and PI in the observation group were lower than those in the control group(P<0.05).The weekly growth of double top diameter,abdominal circumference,head circumference and uterine height in the observation group were better than those in the control group(P<0.05).After treatment,the fetal biophysical score in the observation group was higher than that in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The incidences of very low birth weight infants,premature infants,neonatal asphyxia and fetal distress in the observation group were lower than those in the control group(P<0.05).Conclusion The low molecular weight heparin in the treatment of fetal growth restriction has a significant effect,which can improve the perinatal outcome and promote the healthy growth and development of fetus.