眼区电针治疗血管性痴呆的临床研究

Clinical Study on Vascular Dementia Treated with Electroacupuncture in Eye Area

目的:观察眼区电针治疗血管性痴呆(VD)的临床疗效,并探讨其作用机制。方法:将60例VD患者随机分为两组,即眼针组和常规针刺组,每组30例。两组患者均治疗4周评价疗效;所有患者在治疗前后分别采用简易精神状态检查表(MMSE)评定认知能力,日常生活能力评分量表(ADL-R)评定日常生活能力,NIHSS评分评定神经功能缺损程度;并且测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)含量。结果:眼针组总有效率为83.33%,常规针刺组为66.67%,眼针组优于常规针刺组(P<0.05);两组患者治疗后MMSE评分提高,ADL-R、NIHSS评分降低;血清SOD活性增强,MDA含量和IL-6、TNF-α水平降低;且眼针组上述变化均明显优于常规针刺组(P<0.05)。结论:眼区电针治疗能显著提高血管性痴呆的临床疗效,改善患者认知功能和日常生活能力,可能与其降低患者血清IL-6和TNF-α含量、调节SOD、MDA水平有关。

Objective:To observe the therapeutic effect of Electroacupuncture in eye area on vascular dementia(VD)and explore its mechanism.Methods:60 VD patients were randomly divided into two groups,eye acupuncture group and routine group,with 30 cases in each group.Two groups of patients were treated for 4 weeks to evaluate the curative effect.Before and after treatment,all patients were assessed by MMSE,ADL-R and NIHSS respectively.Serum superoxide dismutase(SOD),malondialdehyde(MDA),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were determined.Results:The total effective rate was 83.33%in the eye acupuncture group and 66.67%in the routine group,and the eye acupuncture group was superior to the routine group(P<0.05).After treatment,MMSE score was raised and ADL-R,NIHSS scores were lowered,serum SOD level was increased,MDA content,and IL-6 and TNF-αlevels were decreased in both groups,and all above changes in the eye acupuncture group were significantly better than those of the conventional group(P<0.05).Conclusion:Eye electroacupuncture can significantly improve the clinical curative effect,improve the cognitive function and daily living ability of patients,that reducing the serum IL-6 and TNF-αcontent and adjusting the levels of SOD and MDA maybe part of its mechanism.