哌拉西林他唑巴坦迟发型变态反应文献分析

Literature analysis of delayed type hypersensitivity by piperacillin tazobactam

目的分析哌拉西林他唑巴坦迟发型变态反应病例,探讨其临床特点及产生原因,为临床合理用药提供参考。方法通过检索PubMed、Medline数据库、中国知网数据库(CNKI)、维普数据库(VIP)和万方数据库,搜集哌拉西林他唑巴坦迟发型变态反应个案和病例系列报道,并对患者性别、年龄、临床表现、临床处理及转归情况进行统计分析。结果筛选出13篇有效文献,共计37例哌拉西林他唑巴坦迟发型变态反应。51.35%该类不良反应发生在50岁以下患者;72.97%病例临床表现以单纯皮肤反应为主;51.35%病例不良反应发生在使用该药物4~21 d;除2例患者快速缓解症状外,35.13%患者转归时间4~14 d,不良反应类型为严重不良反应。结论哌拉西林他唑巴坦迟发型变态反应的个案报道较少,易发人群和发生时间尚不确定,临床应用时应注意监测,确保临床用药安全。

Objective To explore the causes and manifestations of delayed type hypersensitivity by analyzing the cases of delayed type hypersensitivity by piperacillin tazobactam,so as to provide references for clinical treatment. Methods By searching PubMed,Medline,CNKI,VIP and WANFANG database,case reports of delayed type hypersensitivity by piperacillin tazobactam were retrieved.The patients’ gender,age,clinical manifestations and prognosis were also analyzed statistically.Results 13 literatures,37 cases of delayed type hypersensitivity by piperacillin tazobactam were extracted.Statistics showed that 51.35% of these adverse reactions occurred in patients under 50 years old;the clinical manifestations of 72.97% were mainly skin reactions;51.35% of these cases occurred within 4 to 21 days of using piperacillin tazobactam;except for two patient who rapidly relief of symptoms,The turnaround time of 35.13% of patients was 4 to 14 days.The adverse reactions of this type were severe.Conclusion There are few reports of delayed type hypersensitivity by piperacillin tazobactam,but the prone group and allergic reaction time was uncertain.We need pay more attention for piperacillin lazotactam use to ensure the safety of clinical medication.