慢性肾炎患者通过阿托伐他汀、依那普利联合缬沙坦对蛋白尿的影响

Effect of Atorvastatin,Enalapril and Valsartan on Proteinuria in Patients with Chronic Nephritis

目的:探讨阿托伐他汀、依那普利联合缬沙坦治疗对慢性肾炎患者蛋白尿的影响。方法:选择2016年1月~2019年1月某院肾内科收治的60例慢性肾炎患者作为研究对象,按照随机数字表法分为对照组和观察组各30例,对照组选择依那普利、缬沙坦治疗,观察组在依那普利、缬沙坦治疗基础上给予阿托伐他汀,比较两组临床疗效、肾功能指标、血脂指标、血液流变学指标、不良反应发生率。结果:临床总有效率观察组为96.67%,对照组为80.00%,观察组高于对照组(P<0.05);治疗后,观察组的血肌酐、尿素氮、24h尿蛋白水平与对照组相比均更低,观察组的总胆固醇、甘油三酯水平与对照组相比均更低,观察组的红细胞压积、红细胞沉降率、血浆粘度与对照组相比更低(P<0.05);不良反应发生率对照组为3.33%,观察组为6.67%,比较无统计学差异(P>0.05)。结论:阿托伐他汀、依那普利、缬沙坦联合用于慢性肾炎具有良好的临床疗效,可减轻患者肾功能损伤,减少蛋白尿,调低血脂水平,改善血液流变学,还不会增加不良反应,安全性良好。

Objective:To investigate the effect of atorvastatin,enalapril and valsartan on proteinuria in patients with chronic nephritis.Methods:60 cases of chronic nephritis patients treated in a hospital from January 2016 to January 2019 were selected as the research object and divided into two groups according to random number table method,with 30 cases in each group.The control group was treated with enalaprilat and valsartan,and the observation group was given atorvastatin based on the control group,then the clinical curative effect,renal function,blood fat,hemorheology index,incidence of adverse reactions were compared.Results:The clinical total effective rate was 96.67%in the observation group and 80.00%in the control group,and the observation group was higher than the control group(P<0.05).After treatment,the serum creatinine,urea nitrogen,24 h urinary protein levels in the observation group were lower than those in the control group,the total cholesterol and triglyceride levels in the observation group were lower than those in the control group,and the hematocrit,erythrocyte sedimentation rate and plasma viscosity in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 3.33%in the control group and 6.67%in the observation group,with no statistical difference(P>0.05).Conclusion:The combination of atorvastatin,enalapril and valsartan for chronic nephritis has a good clinical effect,which can reduce renal function damage,proteinuria,lower blood lipid level,improve hemorheology,but also not increase adverse reactions,and has a good safety.