乳腺癌免疫组化检测在乳腺癌诊治中的应用

Application of Breast Cancer Immunohistochemical Detection in the Diagnosis and Treatment of Breast Cancer

目的探讨乳腺癌免疫组化检测在乳腺癌患者诊治中的应用价值。方法选择我院2017年6月—2019年6月收治的50例乳腺癌患者,纳入的所有患者均进行细针穿刺明确病理诊断,穿刺完检测ER、PR、P53、her-2等免疫指标,采用环磷酰胺-表柔比星-氟尿嘧啶化疗方案为患者进行化疗,化疗疗程维持3周,随后进行乳腺癌改良根治术切除癌变组织并保留患者乳腺。结果ER、PR、P53以及her-2等指标,ER、PR治疗前后无统计学差异(P>0.05),P53、her-2治疗前后有统计学差异(P<0.05)。ER、PR与患者化疗效果之间无统计学差异(P>0.05),而P53以及her-2与化疗效果之间有统计学差异(P<0.05)。结论乳腺癌免疫组化检测在乳腺癌患者诊治中的应用价值较高,有利于发现相关免疫指标治疗前后差异,从而明确化疗过程中相关化疗药作用机制原理,值得临床推广使用。

Objective To explore the application value of immunohistochemical detection of breast cancer in the diagnosis and treatment of breast cancer.Methods 50 patients with breast cancer treated in our hospital from June 2017 to June 2019 were selected.All the patients were diagnosed by fine needle puncture,and the immune indexes such as ER,PR,P53 and her-2 were detected.Cyclophosphamide-epirubicinfluorouracil chemotherapy was used for the patients.The course of chemotherapy lasted for 3 weeks,and then modified radical mastectomy was performed to remove the cancerous tissue and retain the patient’s breast.Results There was no significant difference in ER,PR,P53 and her-2 before and after ER and PR treatment,but there was significant difference in P53 and her-2 before and after treatment.There was no significant difference between ER,PR and the effect of chemotherapy,but there was significant difference between P53,her-2 and the effect of chemotherapy.Conclusion Immunohistochemical detection of breast cancer is of high value in the diagnosis and treatment of breast cancer,which is helpful to find the difference of relevant immune indexes before and after treatment,so as to clarify the mechanism of action of related chemotherapeutic drugs in the process of chemotherapy,which is worthy of clinical application.