胺碘酮联合美托洛尔对不稳定型心绞痛伴快速心房颤动的疗效观察

Therapeutic Effect of Amiodarone Combined with Metoprolol on Unstable Angina Pectoris with Rapid Atrial Fibrillation

目的分析不稳定型心绞痛伴快速心房颤动的特点,评价胺碘酮+美托洛尔对其进行治疗的临床疗效。方法选择我院2018年5月至2019年8月诊治的不稳定型心绞痛伴快速心房颤动患者,总计66例。按照随机数字表法进行分组治疗,即观察组(n=33)和对照组(n=33),两组患者均予以控制血压、降血糖、抗凝剂、他汀类药物、硝酸酯类药物、双重抗血小板药物等常规治疗,对照组患者在常规治疗基础上加以美托洛尔治疗,观察组患者配合胺碘酮+美托洛尔治疗,对比分析两组患者治疗前后心率变化情况及临床疗效。结果治疗后,观察组患者的心率明显低于对照组[(75.42±6.58)次/分vs.(89.54±8.44)次/分],P<0.05。观察组总有效率为[87.88%(29/33)]明显高于对照组[60.61%(20/33)],两组比较,P<0.05。结论在不稳定型心绞痛伴快速心房颤动患者中应用胺碘酮与美托洛尔联合治疗,可有效提高患者的临床疗效。

Objective To analyze the characteristics of unstable angina with rapid atrial fibrillation,and evaluate the clinical efficacy of amiodarone+metoprolol in the treatment of it.Methods A total of 66 patients with unstable angina and rapid atrial fibrillation who were diagnosed and treated in our hospital from May 2018 to August 2019 were selected.According to the random number table method for group treatment,namely the observation group(n=33)and the control group(n=33),patients in both groups were given blood pressure control,hypoglycemia,anticoagulants,statins,nitrates,dual antiplatelet drugs and other conventional treatments,the control group was treated with metoprolol on the basis of conventional treatment,the observation group was treated with amiodarone+metoprolol,and the HR changes and clinical efficacy of the two groups before and after treatment were compared and analyzed.Results After treatment,the HR of the observation group was significantly lower than that of the control group[(75.42±6.58)times/min vs.(89.54±8.44)times/min],P<0.05.The total effective rate of the observation group was[87.88%(29/33)]was significantly higher than that of the control group[60.61%(20/33)].The comparison between the two groups was P<0.05.Conclusion The combination of amiodarone and metoprolol in patients with unstable angina and rapid atrial fibrillation can effectively improve the clinical ef ficacy of patients.