孟鲁司特钠联合布地奈德治疗肺炎支原体感染致慢性咳嗽患儿的效果

Effect of Montelukast sodium Combined with Budesonide in the Treatment of Children with Chronic Cough Caused by Mycoplasma Pneumoniae Infection

目的探讨孟鲁司特钠联合布地奈德治疗肺炎支原体感染致慢性咳嗽患儿的效果。方法选择2017年5月至2018年5月大连市中心医院收治的100例肺炎支原体感染致慢性咳嗽患儿。根据药物治疗方法的不同随机进行分组,单药组采取布地奈德片治疗,联合组则采取布地奈德片+孟鲁司特钠治疗。比较两组肺炎支原体感染致慢性咳嗽控制率、咳嗽好转时间、感染控制时间、住院时间、治疗前后的炎性指标和免疫指标以及不良反应发生情况。结果联合组肺炎支原体感染致慢性咳嗽治疗有效率、咳嗽好转时间、感染控制时间、住院时间、治疗后CRP水平、IL-6水平、IgG水平、IgA水平均优于单药组,差异均有统计学意义(P<0.05)。联合组和单药组不良反应发生率比较,差异无统计学意义(P>0.05)。结论布地奈德片+孟鲁司特钠治疗肺炎支原体感染致慢性咳嗽患儿的效果较好,有助于及时控制病情,且不良反应较少。

Objective To investigate the clinical efficacy and safety of sequential therapy of erythromycin and azithromycin for mycoplasma pneumoniae infection in children.Methods We selected 100 children with chronic cough caused by mycoplasma pneumoniae infection admitted to Dalian Central Hospital from May 2017 to May 2018.According to the different drug treatment methods,they were randomly divided into two groups.The singledrug group was treated with budesonide tablets,and the combination group was treated with budesonide tablets+montelukast sodium.The control rate of chronic cough caused by mycoplasma pneumoniae infection,cough improvement time,infection control time,hospital stay,inflammatory and immune indicators before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The effective rate of treatment of chronic cough caused by mycoplasma pneumoniae infection,cough improvement time,infection control time,hospitalization time,CRP level,IL-6 level,IgG level,and IgA level after treatment in the combination group were better than the single-drug group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the combination group and the single-drug group(P>0.05).Conclusion Budesonide tablets and montelukast sodium are effective in treating children with chronic cough caused by mycoplasma pneumoniae infection,which is helpful for timely control of the disease and has fewer adverse reactions.