白内障患者NOS、DPP及TFAR19蛋白的表达及临床意义

Expression and clinical significance of NOS,DPP and TFAR19 in patients with cataract

目的分析白内障患者一氧化氮合酶(NOS)、二肽基肽酶(DPP)及凋亡相关蛋白19(TFAR19)的表达及临床意义。方法选取2017年5月至2018年5月本院收治的64例白内障患者作为观察组,以患者病变周围巩膜正常组织为对照组。对比观察组与对照组NOS水平及DPP、TFAR19表达情况,分析NOS、DPP、TFAR19的表达与白内障患者临床特征的关系,采用Logistic回归模型分析影响患者术后视力预后的独立危险因素。结果观察组NOS水平高于对照组,DPP及TFAR19阳性表达率显著高于对照组,差异均具有统计学意义(P<0.05)。NOS、DPP及TFAR19的表达与白内障患者年龄呈显著正相关(P<0.05),与患者性别、不同类型、合并糖尿病、合并高血压之间无显著相关性(P>0.05)。性别、不同类型、合并高血压为非影响白内障患者术后视力预后的单因素(P>0.05);年龄、合并糖尿病、NOS、DPP、TFAR19为影响患者术后矫正视力预后的单因素(P<0.05)。选取有条件的单因素经非条件多因素Logistic回归模型进一步分析,得出:年龄(≧65岁)、NOS表达(高水平)、DPP表达(阳性)、TFAR19表达(阳性)影响白内障患者术后视力预后的独立危险因素(P<0.05)。结论NOS、DPP、TFAR19在白内障患者中呈高表达,NOS、DPP、TFAR19的表达与患者年龄之间有密切联系,上述指标表达过高会影响患者手术矫正视力预后。

Objective To analyze the expression and clinical significance of nitric oxide synthase(NOS),dipeptidyl peptidase(DPP)and Apoptosis⁃associated protein 19(TFAR19)in patients with cataract.Methods 64 patients with cataracts admitted to our hospital from May 2017 to May 2018 were selected as the observation group,and the normal sclera tissue around the disease was selected as the control group.The NOS level and the expression of DPP and TFAR19 between the observation group and the control group were com⁃pared,and the relationship between the expression of NOS,DPP,and TFAR19 and the clinical characteristics of cataract patients was analyzed.Logistic regression model was used to analyze the independent risk factors that affect the prognosis of postoperative visual acuity of patients.Results The NOS level of the observation group was higher than that of the healthy group,and the positive expression rate of DPP and TFAR19 was significant⁃ly higher than that of the control group(P<0.05).The expression of NOS,DPP and TFAR19 was closely relat⁃ed to the age of patients with cataract(P<0.05),and was no significant correlation with the gender,different types,combined diabetes,and high blood pressure(P>0.05).Gender,different types,and combined hyperten⁃sion are not the single factors that affect the prognosis of postoperative vision in patients with cataract(P>0.05).Age,combined diabetes,NOS,DPP,and TFAR19 are the single factors affecting the prognosis of patients with postoperative corrected vision(P<0.05).The conditional single factor was selected and further analyzed by the unconditional multivariate logistic regression model,and it showed that age(≧65 years),NOS expression(high level),DPP expression(positive),TFAR19 expression(positive)affects are independent risk factors that affect the prognosis of postoperative vision in patients with cataract(P<0.05).Conclusion NOS,DPP,and TFAR19 are highly expressed in patients with cataract.The expression of NOS,DPP,and TFAR19 is close⁃ly related to the patient􀆳s age.Excessive expression of the above indicators will affect the prognosis of corrected visual acuity after surgery of patients.