急性百草枯中毒对患者认知功能的影响

Effects of acute paraquat poisoning on cognitive ability in humans

目的探究急性百草枯中毒对患者认知功能的影响。方法于2019年6月,选择河北省某省级医院急诊科2017年急性百草枯中毒经救治存活患者作为病例组,共36例;选取健康个体36例,作为对照组。采用《简易精神状态量表》、听觉词语学习测验、数字广度测验、连线测验、波士顿命名测验和《老年抑郁量表》对受试者认知功能及抑郁情绪状态进行评估。结果《简易精神状态量表》结果显示,病例组总分较对照组降低,差异有统计学意义(P<0.05)。听觉词语学习测验结果显示,病例组延迟回忆、线索回忆和辨正能力等得分低于对照组,差异均有统计学意义(P<0.05),两组即刻记忆得分差异无统计学意义(P>0.05)。与对照组比较,病例组数字广度测验得分较低、连线测验时间较长、波士顿命名测验得分较低,差异均有统计学意义(P<0.05)。结论急性百草枯中毒可对患者认知功能产生不良影响。

Objective To explore the effects of acute paraquat poisoning on cognitive function of patients through neuropsychologic test.Methods In June 2019,36 patients with acute paraquat poisoning in the emergency department of a provincial hospital in Hebei Province were selected as the case group.36 healthy individuals were selected as control group.The cognitive function and depressive state were assessed by mini mental state scale,auditory word learning test,digit span test,connection test,Boston Naming Test and geriatric depression scale.Results The results of Mini-Mental State examination showed that the total score of the case group was lower than that of the control group,the difference was statistically significant(P<0.05).The results of the Auditory Vocabulary Learning test showed that the scores of delayed recall,clue recall,corrective ability and semantic learning strategies of the case group were significantly lower than those in the control group(P<0.05).There was no significant difference in the scores of immediate memory between the two groups(P>0.05).The scores of Digit Span test and Boston Naming test in the control group were higher than those in the case group,the Trail Making test time in the control group was shorter than that in the case group,and the differences were statistically significant(P<0.05).Conclusion Acute paraquat poisoning can impair human cognitive ability to a certain extent.