职业性镍接触对作业工人血糖相关指标的影响

Effects of occupational nickel exposure on glycemic parameters in workers

目的探讨职业性镍接触对作业工人血糖相关指标的影响。方法于2019年3月,采用整群抽样方法选择5家电镀企业及1家塑料五金企业,以159名镀镍工人作为接触组,以66名同企业行政管理人员作为对照组。检测接触组和对照组人群的血镍浓度,以及空腹血糖(FPG)、空腹胰岛素(FIns)和糖化血红蛋白(HbA1c)水平。比较两组间血糖相关指标的差异,分析血糖指标异常的危险因素。结果与对照组比较,接触组血镍浓度及镍检出率较高,FIns水平较低,HbA1c比例较高,差异均有统计学意义(P<0.05)。分层分析显示,与对照组比较,接触组男性血糖指标变化明显(P<0.05);logistic回归分析显示,男性是FIns降低的独立影响因素(OR=8.264,P<0.05)。结论长期镍接触会对FIns、HbA1c等血糖相关指标有一定的影响。

Objective To explore the effect of occupational nickel exposure on blood glucose related indicators of workers.Methods In March 2019,five electroplating enterprises and one plastic hardware enterprise were selected by cluster sampling method.159 nickel plating workers were selected as the contact group,and 66 administrative personnel of the same enterprise were selected as the control group.The serum nickel concentration,fasting blood glucose(FPG),fasting insulin(FIns)and glycosylated hemoglobin(HbA1c)were measured in the contact group and the control group.The differences of blood glucose related indexes between the two groups were compared,and the risk factors of abnormal blood glucose indexes were analyzed.Results Compared with the control group,the blood nickel concentration and detection rate of nickel in the contact group were higher,the levels of FIns were lower,and the proportion of HbA1c was higher in the contact group(P<0.05).Stratified analysis showed that compared with the control group,the blood glucose index of men in the contact group changed significantly(P<0.05);logistic regression analysis showed that male was an independent influencing factor for decreased FIns(OR=8.264,P<0.05).Conclusion Long term exposure to nickel can affect the blood glucose related indexes such as fins and HbA1c.