多囊卵巢综合征患者IVF助孕卵母细胞质量及胚胎发育指标分析

Analysis of Oocyte Quality and Embryo Development of PCOSPatients Using IVF

目的研究多囊卵巢综合征(PCOS)患者经过超促排卵后其卵母细胞质量及胚胎发育情况。方法采用非随机分组数据,回顾性分析2017年1月至2018年12月期间我中心行常规体外受精(in vitro fertilization,IVF)多囊卵巢综合征患者266例,同时纳入1064例单纯输卵管因素不孕症患者作为对照组。对两组的卵母细胞质量进行评估,比较2组患者的获卵数、卵母细胞成熟度、卵母细胞正常受精率、可用胚胎率及囊胚形成率。结果与对照组相比,PCOS组患者的获卵数和成熟卵母细胞数、受精卵数、正常受精卵数、卵裂期胚胎数多于对照组患者(P<0.05);PCOS组患者的卵母细胞成熟率、卵母细胞受精率、卵母细胞正常受精率、胚胎卵裂率、可用胚胎数、可用胚胎率、囊胚形成数、囊胚形成率均低于对照组(P均<0.05)。对两组患者新鲜周期妊娠结局进行分析,结果显示,两组患者临床妊娠率、异位妊娠率、流产率差异无统计学意义(P均>0.05),PCOS组患者的活产率低于对照组(P<0.05)。结论PCOS患者虽然获卵数增加,但卵母细胞成熟度明显下降,可能是导致后续卵母细胞正常受精率、卵裂率、可用胚胎率、囊胚形成率及活产率降低的主要原因之一。

Objective To study the oocyte quality and embryo development of PCOS patients by in vitro fertilization(IVF).Methods Using non randomized data,266 patients with infertility factor of PCOS in our center from January 2017 to December 2018 as research group and 1064 patients with infertility due to simple fallopian tube as the control group were retrospectively analyzed.The oocyte quality of the two groups was evaluated,and the number of and blastocyst formation rate of each group was investigated.Results The number of oocytes obtained,mature oocytes,fertilized eggs,normal fertilized eggs and embryos in cleavage stage in PCOS patients were significantly higher than that of the control group.However,the oocyte maturity,normal fertilization rate of oocytes,cleavage rate,available embryo number,available embryo rate and Blastocyst formation number,and blastocyst formation rate of PCOS patients all decreased,and the above differences were statistically significant(P all<0.05).Compared The pregnancy outcomes between the two groups showed that there was no significant difference in clinical pregnancy rate,ectopic pregnancy rate and abortion rate between the two groups(P all>0.05).The live birth rate of PCOS group was lower than that of control group(P<0.05).Conclusion Although the number of oocytes obtained increased in PCOS patients,the results showed that the oocyte maturity decreased significantly,which may be one of the main reasons for the significant decrease of normal fertilization rate,cleavage rate,available embryo rate,blastocyst formation rate and live rate of subsequent oocytes.