痛泻要方联合西药治疗对腹泻型肠易激综合征患者结肠黏膜5-HT3受体表达的影响

Effect of Tongxie Yaofang combined with western medicine on 5-HT3 receptor expression in colonic mucosa of patients with diarrhea-type irritable bowel syndrome

目的:探究痛泻要方联合西药治疗对腹泻型肠易激综合征(IBS-D)患者结肠黏膜5-HT3受体表达的影响。方法:选取82例IBS-D患者,按随机数字表法分为两组,每组各41例。对照组给予西药治疗,在西药治疗基础上研究组联合痛泻要方治疗。对比两组总有效率、治疗前后中医证候积分、血液各指标水平及不良反应。结果:研究组总有效率为95.12%,高于对照组的68.29%,差异有统计学意义(P<0.05);治疗后,研究组少腹拘急积分为(0.94±0.06)分、腹痛即泻积分为(1.03±0.21)分、胸胁胀满积分为(1.00±0.16)分、便下黏液证候积分为(0.93±0.04)分,均低于对照组的(1.29±0.43)分、(1.94±0.37)分、(1.86±0.25)分、(1.31±0.25)分,差异有统计学意义(P<0.05);研究组治疗后5-HT3受体mRNA表达丰度为(0.45±0.06),低于对照组的(0.53±0.08),差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:痛泻要方联合西药治疗IBS-D疗效确切,可有效降低各中医证候积分,减少5-HT3受体mRNA表达丰度,且安全可靠。

Objective:To explore the effect of Tongxie Yaofang combined with western medicine on the expression of 5-HT3 receptor in colonic mucosa of patients with diarrheal irritable bowel syndrome(IBS-D).Methods:A total of 82 patients with IBS-D were selected and divided into two groups according to the random number table method,with 41 cases in each group.The control group was treated with western medicine,and the study group was treated with Tongxie Yaofang on the basis of western medicine.The total effective rate,TCM syndrome scores before and after treatment,blood levels and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.12%,which was higher than 68.29%of the control group,the difference was statistically significant(P<0.05).After treatment,the Shaofu Juji score of the study group was(0.94±0.06)points,abdominal pain and diarrhea score was(1.03±0.21)points,the score for fullness of the chest and flank was(1.00±0.16)points,and the score for stool mucus syndrome was(0.93±0.04)points,which were all lower than the control group’s(1.29±0.43)points,(1.94±0.37)points,(1.86±0.25)points,(1.31±0.25)points,the difference was statistically significant(P<0.05).The 5-HT3 receptor mRNA expression abundance of the study group after treatment was(0.45±0.06),Lower than the control group(0.53±0.08),the difference was statistically significant(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:Tongxie prescription combined with western medicine has a definite effect in the treatment of IBS-D.It can effectively reduce the scores of various TCM syndromes and reduce the abundance of 5-HT3 receptor mRNA expression.It is safe and reliable.