三种典型上皮因子在治疗过敏性哮喘中的研究进展

Research progress of three typical epithelial cytokinesin the treatment of allergic asthma

在支气管哮喘(哮喘)的发病机制中,不同个体存在不同的表型和内型,针对不同表型和内型的个体化治疗或者精准治疗是目前乃至今后治疗的发展趋势。上皮因子是各类亚型哮喘的重要始动和促进因子,尤其是过敏性哮喘。更好地理解与分析上皮因子的内型以及它们如何影响气道免疫反应,可能对今后哮喘的个体化治疗产生重要影响。本文综述了3种典型的上皮因子的特征、功能和目前在哮喘治疗中的研究进展。

In the pathogenesis of bronchial asthma(asthma),different individuals have different phenotypes and endotypes.Individualized or precision therapy for different phenotypes and endotypes is a therapeutic trend at present and even in the future.Epithelial cytokines are important initiators and promoters of various subtypes of asthma,especially allergic asthma.A better understanding of the endotype of epithelial cytokines and how they affect the airway immune response may have important implications for individualized therapy of asthma in the future.We provide an overview of the characteristics,functions and current research progress in the treatment of asthma of three typical epithelial cytokines.