止咳一号方联合常规西医治疗慢性阻塞性肺疾病急性加重期的临床效果

Clinical Effect of Zhike No.1 Prescription Combined with Conventional Western Medicine in the Treatment of Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation Stage

目的:探究止咳一号方联合常规西医在治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果。方法:选取2019年3月-2020年3月本院接受治疗的AECOPD患者68例,按随机数字表法分为对照组和研究组,各34例。对照组行常规西医治疗,研究组行止咳一号方联合常规西医治疗。对比两组临床疗效、治疗前后血气指标[酸碱度(pH)、动脉二氧化碳分压(PaCO2)、动脉氧分压(PaO2)]及肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最高呼气流速(PEF)]。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组治疗后PaCO2水平低于对照组,PaO2、FEV1、FVC、PEF水平高于对照组,差异有统计学意义(P<0.05)。两组pH值比较差异无统计学意义(P>0.05)。结论:止咳一号方联合常规西医在AECOPD治疗中效果确切,有助于缓解患者病情,改善血气指标,提高肺功能。

Objective:To explore the clinical efficacy of Zhike No.1 Prescription combined with conventional western medicine in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Method:A total of 68 AECOPD patients who received treatment in our hospital from March 2019 to March 2020 were selected and divided into the control group and the study group according to the random number table method,with 34 cases in each group.The control group was treated with conventional western medicine,and the study group was treated with Zhike No.1 Prescription combined with conventional western medicine.The clinical efficacy,blood gas indexes[potential of hydrogen (pH),partial pressure of arterial carbon dioxide (PaCO2),partial pressure of arterial oxygen (PaO2)]and lung function[forced vital capacity (FVC),forced expiratory volume in one second (FEV1),peak expiratory flow (PEF)]before and after treatment were compared between the two groups.Result:The total therapeutic effective rate of the study group was higher than that of the control group,the difference was statistically significant (P<0.05).After treatment,the PaCO2 level of the study group was lower than that of the control group,and the levels of PaO2,FEV1,FVC,PEF of the study group were higher than those of the control group,the differences were statistically significant (P<0.05).There was no significant difference in pH between the two groups (P>0.05).Conclusion:The Zhike No.1 Prescription combined with conventional western medicine has a definite effect in the treatment of AECOPD,which can help relieve the patients’ condition,improve blood gas indexes,and improve lung function.