高敏C反应蛋白联合中性粒细胞淋巴细胞比值预测急性心肌梗死后恶性心律失常的临床价值

Clinical Value of High Sensitivity C-reactive Protein Combined with Neutrophil Lymphocyte Ratio in Predicting Malignant Arrhythmia after Acute Myocardial Infarction

目的:探讨高敏C反应蛋白(hs-CRP)联合中性粒细胞淋巴细胞比值(NLR)预测急性心肌梗死(AMI)后恶性心律失常的临床价值。方法:选取2017年1月-2020年3月就诊于本院的90例AMI患者作为观察组,选择同期于本院行健康体检的90例健康者为对照组。比较两组血清hs-CRP、NLR;比较合并恶性心律失常和非恶性心律失常AMI患者血清hs-CRP、NLR,分析hs-CRP、NLR单一和联合诊断预测AMI后恶性心律失常的价值。结果:观察组血清hs-CRP、NLR高于对照组,差异有统计学意义(P<0.05);合并恶性心律失常AMI患者的血清hs-CRP、NLR高于非恶性心律失常AMI患者,差异有统计学意义(P<0.05)。hs-CRP、NLR联合诊断预测AMI后恶性心律失常的曲线下面积(AUC)为0.892,特异度与敏感度分别为71.45%、87.56%;hs-CRP、NLR单一预测AMI后恶性心律失常的曲线下面积(AUC)分别为0.703、0.751,特异度分别为76.15%、88.14%,敏感度分别为50.95%、61.19%。结论:AMI后恶性心律失常患者hs-CRP、NLR明显升高,hs-CRP、NLR联合诊断预测AMI后恶性心律失常敏感度较高,可将其作为筛查AMI后恶性心律失常指标。

Objective:To investigate the clinical value of high sensitivity C-reactive protein (hs-CRP) combined with neutrophil lymphocyte ratio (NLR) in predicting malignant arrhythmia after acute myocardial infarction (AMI).Method:A total of 90 AMI patients who were treated in our hospital from January 2017 to March 2020 were selected as the observation group,and 90 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group.The serum hs-CRP and NLR between the two groups were compared.The serum hs-CRP and NLR of AMI patients with malignant arrhythmia and non-malignant arrhythmia were compared,and the value of hs-CRP and NLR single and combined diagnosis for predicting malignant arrhythmia after AMI was analyzed.Result:The serum hs-CRP and NLR of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05);the serum hs-CRP and NLR of AMI patients with malignant arrhythmia were higher than those of AMI patients with non-malignant arrhythmia,the differences were statistically significant (P<0.05).The area under the curve (AUC) of the combined diagnosis of hs-CRP and NLR for predicting malignant arrhythmia after AMI was 0.892,and the specificity and sensitivity were 71.45% and 87.56%,respectively.The AUC of the single diagnosis of hs-CRP and NLR for predicting malignant arrhythmia after AMI were 0.703 and 0.751,the specificity was 76.15% and 88.14%,and the sensitivity was 50.95% and 61.19%.Conclusion:The hs-CRP and NLR are significantly increased in patients with malignant arrhythmia after AMI.The combined diagnosis of hs-CRP and NLR has high sensitivity in predicting malignant arrhythmia after AMI,and it can be used as an indicator to screen for malignant arrhythmia after AMI.