BDNF-TrkB信号通路基因及其编码蛋白在癫痫中的作用研究进展

Recent advance in roles of brain-derived neurotrophic factor-tyrosine receptor kinase B signaling pathway genes and their encoded proteins in epilepsy

脑源性神经营养因子(BDNF)-酪氨酸激酶受体B(TrkB)信号通路在多种神经系统疾病尤其在癫痫的发生、发展和治疗中可能具有重要的作用。BDNF基因和NTRK2基因分别是该信号通路中编码BDNF蛋白和TrkB蛋白的基因,这2个基因的变异可能导致其编码蛋白的功能和表达异常,影响BDNF-TrkB通路活化程度,进而影响癫痫的发生和治疗。本文围绕BDNF-TrkB信号通路基因及其编码蛋白在癫痫中的作用研究进展综述如下。

Brain-derived neurotrophic factor(BDNF)and tyrosine receptor kinase B(TrkB)signaling pathway may play important roles in a variety of neurological diseases,particularly in the development and treatment of epilepsy.The BDNF gene and NTRK2 gene are genes encoding BDNF and TrkB proteins in this pathway.The variations in these two genes may affect the occurrence and treatment of epilepsy through leading to abnormal functions and expressions of the encoded proteins,which may affect the degrees of activation of BDNF-TrkB signaling pathway.This article summarizes the pathophysiological processes of epilepsy in which BDNF-TrkB signaling pathway genes and their encoded proteins may be involved.