摘要
微小RNAs(miRNAs)是一种高度保守的短链非编码RNA,在分子层面上调控生命活动。miRNAs活跃在缺血性脑卒中后自噬的各个阶段,发挥着脑保护作用和破坏作用。本文以自噬过程为线索,围绕自噬相关基因(Atg)或通路探讨miRNAs调控自噬在缺血性脑卒中中的可能作用机制进行综述,分析其在脑卒中诊疗中的应用前景。
Micro RNAs are a kind of conserved short non-coding RNAs that regulate life activities at molecular level.Micro RNAs are active in various stages of autophagy after ischemic stroke;micro RNAs play protective or destructive roles in autophagy after stroke.Based on the autophagy process,we discuss the possible mechanism of autophagy regulated by micro RNAs through autophagy related genes or pathways,and analyze the application prospect of micro RNAs in stroke diagnosis and treatment.
作者
吴茂东
苏清伦
刘臻
杜海敏
陆静
孙振杰
Wu Maodong;Su Qinglun;Liu Zhen;Du Haimin;Lu Jing;Sun Zhenjie(Department of Rehabilitation,Lianyungang First People's Hospital Affiliated to Kangda College of Nanjing Medical University,Lianyungang 222000,China;Department of Neurolgy,Lianyungang First People's Hospital Affiliated to Kangda College of Nanjing Medical University,Lianyungang 222000,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2020年第12期1277-1282,共6页
Chinese Journal of Neuromedicine
基金
江苏省科研实践与创新计划(SJCX18_0713)。
