摘要
宫颈脱落的滋养细胞能提供胎儿完整的遗传信息,以及与胎盘功能不全相关的不良妊娠结局的信息。现综述宫颈脱落滋养细胞的取样、鉴定、分离富集方法,以及产前检测应用的相关研究进展,以期探讨将其作为一种无创产前检测样本的可行性。
Trophoblasts shedding from the cervix,with intact nuclear DNA,can provide complete genetic information of the fetus and can even predict adverse pregnancy outcomes related to placental dysfunction.In this review,we discuss the progress of techniques for the sampling,identification,isolation and enrichment of the trophoblast cells shedding from the cervix and its value in prenatal diagnosis and explore the feasibility of recovering trophoblasts from the cervix as a non-invasive prenatal detection sample.
作者
刘丛丛
刘俊涛
Liu Congcong;Liu Juntao(Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2020年第12期849-853,共5页
Chinese Journal of Perinatal Medicine
基金
国家重点研发计划(2019YFC1005105)。
关键词
滋养层
产前诊断
子宫颈
细胞分离
Trophoblasts
Prenatal diagnosis
Cervix uteri
Cell separation