白塞综合征患者疾病活动性的相关因素分析

Analysis on factors related to disease activity of patients with Behcet disease

目的·分析白塞综合征(白塞病,Behcet disease,BD)患者疾病活动性的相关因素。方法·收集2013年1月—2018年12月上海交通大学医学院附属仁济医院南院风湿免疫科收治并确诊为BD的178例患者的临床病历资料,分析患者的临床表现及实验室指标;利用电子病历疾病活动性指数(electronic medical record-based activity index,EMRAI)评分系统对疾病活动性进行评分,并通过单因素分析和Logistic回归模型分析其相关影响因素。结果·178例BD患者中男女比例为1.67:1。单因素分析结果显示,不同性别、受教育程度、病程长短的患者之间,有无C反应蛋白异常、阵发性腹痛和体温升高的患者之间EMRAI评分差异有统计学意义(均P<0.05)。多因素Logistic回归分析结果显示,EMRAI评分的相关因素为病程、C反应蛋白和治疗方案(均P<0.05)。结论·BD患者的疾病活动性与患者病程、C反应蛋白与治疗方案之间具有相关性。

Objective·To analyze the related factors of disease activity of Behcet disease(BD)patients.Methods·The clinical records of 178 patients with BD who were admitted to the Department of Rheumatology and Immunology,Renji Hospital South Campus,Shanghai Jiao Tong University School of Medicine from January 2013 to December 2018 were collected,and the clinical manifestations and laboratory indexes of the patients were analyzed.Electronic medical record-based activity index(EMRAI)was used to evaluate the disease activity,of which the related factors were explored by univariate analysis and Logistic regression analysis.Results·The ratio of males to females in 178 BD patients was 1.67:1.The results of single factor analysis showed that there were statistically significant differences in EMRAI scores among the patients with different genders,education levels and courses of disease,as well as between the patients with or without abnormal C-reactive protein,paroxysmal abdominal pain and temperature rise(P<0.05).Multivariate Logistic regression analysis showed that the related factors of EMRAI score were course of disease,C-reactive protein and treatment plan(P<0.05).Conclusion·The disease activity of BD patients is correlated with the course of disease,C-reactive protein and treatment plan.