窄谱中波紫外线联合卡泊三醇治疗银屑病症状转归及患者治疗前后外周血细胞因子水平评价

Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol

目的分析窄谱中波紫外线治疗银屑病临床疗效以及对患者外周血细胞因子的影响。方法选取2018年5月至2020年3月昆明医科大第一附属医院治疗的银屑病患者109例,按照随机数字表法分为观察组(n=55)和对照组(n=54),对照组采取卡泊三醇软膏治疗,观察组联合窄谱中波紫外线治疗,对比两组临床疗效以及患者外周血细胞因子变化情况。结果观察组患者临床治疗总有效率高于对照组,差异有统计学意义(P <0.05);观察组患者治疗后Th17、Treg、Th17/Treg与对照组比较,差异有统计学意义(P <0.05)。观察组患者治疗后TNF-α、IL-10与对照组比较,差异有统计学意义(P <0.05)。结论窄谱中波紫外线治疗银屑病可以提升临床治疗效果,可能同抑制银屑病患者血清TNF-α和Th17水平、提高1L-10、Treg细胞水平有关,窄谱中波紫外线可以通过改善患者Th17/Treg细胞失衡比例以及细胞因子水平发挥作用,值得临床推广。

Objective To analyze the clinical efficacy of narrow-spectrum UVB in the treatment of psoriasis and the effect on peripheral blood cytokines.Methods 109 patients with psoriasis treated in the First Affiliated Hospital of Kunming Medical University from May 2018 to March 2020 were selected and randomly divided into experimental group(n=55)and control group(n=54).The control group was treated with capotriol ointment,and the experimental group was treated with narrow-spectrum UVB combined with capotriol ointment.The clinical efficacy and the changes of cytokines in peripheral blood of patients in the two groups were compared.Results The total effective rate of clinical treatment in the experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,Th17,Treg and Th17/Treg in the experimental group were statistically significant in control group(P<0.05).After treatment,TNF-radiation and il-10 in the experimental group were compared with those in the control group,and the difference was statistically significant(P<0.05).Conclusion Narrow spectrum UVB treatment of psoriasis can improve the clinical outcomes,which may be related to the inhibition of serum TNF-beam and Th17 levels in patients with psoriasis,and the improvement of 1l-10 and Treg cell levels.UVB in narrow spectrum may play a role in improving Th17/Treg imbalance ratio and cytokine levels in patients with psoriasis,which has great potential in clinical practice.