C反应蛋白/白蛋白比值与老年心力衰竭患者长期预后的关系

Association between C-reactive Protein/Albumin Ratio and Long-term Prognosis in Elderly Patients with Heart Failure

目的探讨C反应蛋白与白蛋白比值(hs-CRP/Alb)与心力衰竭老年患者长期预后之间的关系。方法以65~70岁老年心力衰竭患者为研究对象,共125例,按照预后情况分为良好预后组(n=75)以及不良预后组(n=50),对比两组hs-CRP/Alb比值、NYHA心功能分级、脑钠肽、血钠、总胆固醇、血红蛋白等一般资料,使用多因素COX回归和Logistic回归分析CRP/Alb比值对老年心力衰竭患者预后评估的能力以及影响该比值的相关因素。结果良好预后组hs-CRP/Alb比值显著低于不良预后组,差异有统计学意义(P> 0.05);不良预后组hs-CRP/Alb比值> 0.38,是发生不良预后的独立危险因素,而高年龄、高水平脑纳肽、高NYHA心功能分级、低血钠、低总胆固醇以及低水平血红蛋白是是hs-CRP/Alb比值低的独立危险因素。结论 C反应蛋白/白蛋白比值是反应心力衰竭患者预后情况的良好指标。

Objective To investigate the association between the ratio of C-reactive protein to albumin(HSCRP/Alb)and long-term prognosis in elderly patients with heart failure.Methods A total of 125 aged 65-70 patients with heart failure were enrolled as the research subjects,and retrospective cohort analysis was conducted.Subjects were divided into 2 groups based on prognosis as good prognosis group(n=75),and poor prognosis group(n=50).We compared hs CRP/propagated ratio,NYHA heart function classification,brain natriuretic peptide and blood sodium,total cholesterol,hemoglobin and other general information of the two groups;and usd multiariable COX regression and Logistic regression analysis of CRP/propagated ratio of capacity to evaluate the prognosis of patients with senile heart failure as well as the related factors affecting the ratio.Results The hscrp/Alb ratio in the good prognosis group was significantly lower than that in the poor prognosis group(P>0.05).In the poor prognosis group;the hs-crp/Alb ratio of>0.38 was an independent risk factor for poor prognosis,while ageing,high level of brain peptide,high NYHA grade of heart function,low serum sodium,low total cholesterol and low level of hemoglobin were independent risk factors for low hs-crp/Alb ratio.Conclusion C-reactive protein/albumin ratio is a good indicator of prognosis in patients with heart failure.