摘要
细胞周期检查点激酶1(checkpoint kinase 1,Chk1)是一种在细胞周期内对受损DNA起重要作用的蛋白激酶,可以对DNA进行及时修复,来保证进入有丝分裂前的基因完整性。Chk1表达的高低与肿瘤的发生发展有密切关系,基于Chk1在细胞周期中的独特作用机制,目前有大量Chk1抑制剂正在进行研究。本文综述了Chk1的作用机制,及其与肿瘤的关系,以及近些年来Chk1抑制剂的临床研究。
Checkpoint kinase 1(Chk1)is a protein kinase,which plays an important role in repairing damaged DNA timely during the cell cycle,ensuring the integrity of gene before entering into the mitosis.The expression of Chk1 is closely associated with the occurrence and growth of the tumor.Based on the Chk1’s unique mechanism,a large number of studies about Chk1 inhibitors is ongoing.This review discussed not only the mechanism of Chk1,but also the relation between Chk1 and tumor,and clinical studies about Chk1 inhibitors in recent years.
作者
岳厚汝
薛佳兴
易俊希
徐尧
焦炳华
卢小玲
YUE Houru;XUE Jiaxing;YI Junxi;XU Yao;JIAO Binghua;LU Xiaoling(16th Cadet,Naval Medical University Student Brigade,Shanghai 200433,China;Department of Biochemistry and Molecular Biology,Naval Medical University,Shanghai 200433,China)
出处
《生命的化学》
CAS
CSCD
2020年第10期1738-1750,共13页
Chemistry of Life
基金
国家重点研发计划项目(2019YFC0312504)。