促黄体生成素诱导卵巢排卵的调控

Regulation of ovarian ovulation induced by luteinizing hormone

排卵发生在卵母细胞成熟过程中的特定时间,随后具有发育能力的卵母细胞进入输卵管中等待受精。垂体促性腺激素的作用启动了排卵,卵泡膜细胞、壁颗粒细胞、卵丘细胞分泌的旁分泌因子和卵母细胞自身共同作用介导整个排卵过程。结果导致了卵丘细胞扩散、蛋白水解、血管生成、炎症反应和平滑肌的收缩。这些过程都是卵泡破裂所必需的。小鼠模型中的研究很好地阐述了上述过程细胞间的信号交流,并且与包括人类在内的脊椎动物具有高度保守性。本文将对促黄体生成素诱导的卵巢排卵的调控作一阐述。

Ovulation occurs at specific time during the maturation of the oocyte,and then the developing oocyte enters the oviduct to wait for fertilization.The action of the pituitary gonadotropin initiates ovulation,and the paracrine factors secreted by the theca cells,mural granulosa cells,cumulus cells and the oocytes themselves mediate the entire ovulation process.And then lead the induction of cumulus expansion,proteolysis,angiogenesis,inflammation and smooth muscle contraction,which are required for follicular rupture.The research in the mouse model has explained the signal communication between cells in the above process,and it is highly conserved with vertebrates including humans.This review will explain the regulation of ovarian ovulation induced by luteinizing.