血管新生的双向信号调控

The signaling pathway in the angiogenesis control

血管新生是内皮细胞在原有毛细血管或微静脉系统上经过分化、增殖、迁移生成的新的血管。在机体缺血缺氧时促进血管新生有利于恢复供血,在肿瘤、血管增生性眼病中需要进行抗血管生成治疗。但机体对血管新生不是单一的促进或抑制,而是一个双向调节的过程。本文主要综述血管新生的双向调节及Caveolae/Caveolin-1、AMPK、TGF-β/Smad等信号通路在其中的作用。

Angiogenesis is a new blood vessel formed by the differentiation,proliferation and migration of endothelial cells on the original capillary or venule system.Promoting angiogenesis during ischemia and hypoxia is beneficial to restore blood supply,while anti-angiogenesis therapy is needed in tumors and vascular proliferative eye diseases.However,the angiogenesis of the body is not a single promotion or inhibition,but a two-way regulation process.This paper reviews the bidirectional regulation of Caveolae/Caveolin-1,AMPK,TGF-β/Smad signaling pathways on angiogenesis.