盐酸氨溴索治疗慢性阻塞性肺疾病合并肺部感染的临床效果

Clinical effect of Ambroxol Hydrochloride in the treatment of chronic obstructive pulmonary disease with pulmonary infection

目的探究盐酸氨溴索治疗慢性阻塞性肺疾病(COPD)合并肺部感染的临床效果。方法选取2019年2月~2020年2月广东省阳江市阳东区人民医院治疗的300例COPD合并肺部感染患者,按随机数字表法分为观察组和对照组,每组各150例。观察组采用盐酸氨溴索治疗,对照组用常规方式治疗。比较两组的临床效果、不良反应总发生率、临床症状体征消失时间、生活质量。结果观察组的临床总有效率为97.33%,高于对照组的85.33%,差异有统计学意义(P<0.05)。观察组的不良反应总发生率为6.67%,低于对照组的7.33%,但差异无统计学意义(P>0.05);观察组的胸闷、体温恢复,肺部啰音、咳嗽消失时间短于对照组,差异均有统计学意义(P<0.05);观察组的生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论对COPD合并肺部感染患者采用盐酸氨溴索治疗,安全有效,能取得显著治疗效果,不增加不良反应,缩短胸闷恢复、肺部啰音和咳嗽消失时间,有临床应用价值。

Objective To investigate the clinical effect of Ambroxol Hydrochloride in the treatment of chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods From February 2019 to February 2020,300 patients with COPD and pulmonary infection treated in Yangdong District People′s Hospital of Yangjiang City,Guangdong Province were selected,they were divided into the control group and the observation group according to random number table method,150 cases in each group.The observation group was treated with Ambroxol Hydrochloride,the control group was treated with routine treatment.The clinical curative effect,the total incidence of adverse reactions,the time of disappearance of clinical symptoms and signs,and the quality of life were compared between two groups.Results Clinical efficacy in observation group was 97.33%,higher than 85.33%in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions was 6.67%,lower than 7.33%in the control group,but the difference had no statistical significance(P>0.05).Chest tightness and temperature recovery,lung rales,cough disappeared time in the observation group was shorter than that of the control group,the differences were statistically significant(P<0.05).All the quality of life scores in the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion For patients with COPD complicated with pulmonary infection,treated with Ambroxol Hydrochloride,safe and effective,can achieve remarkable therapeutic effect,no adverse reactions,shorten chest tightness recovery,lung rales and cough loss.It has clinical application value.