AURKA对肿瘤免疫影响的研究进展

The effect of AURKA on cancer immunity

AURKA是一种丝氨酸/苏氨酸激酶,在细胞有丝分裂过程中发挥重要调控作用。AURKA的上调在人类恶性肿瘤中普遍存在。大量研究已经证实,AURKA作为一种癌基因,影响了众多肿瘤生物学过程,如增殖、基因组不稳定、非整倍体核型的产生和侵袭转移等。近年来,一些研究发现AURKA与肿瘤免疫之间也存在密切关联。人们对AURKA影响免疫反应的最初认识来源于其在免疫治疗中的应用。AURKA的抗原决定簇可以启动抗AURKA免疫反应,借以杀伤高表达AURKA的肿瘤细胞。另外,有研究发现抑制AURKA可以通过诱导细胞转化、T细胞活化和免疫细胞浸润而直接干预免疫反应。文章对AURKA参与免疫调控的相关发现进行了回顾和总结。

AURKA is a serine/threonine kinase and has a key role in regulation of mitosis.Moreover,upregulation of AURKA has been identified in a wide range of human malignancy.Functioning as an oncogene,AURKA influences multiple biological processes of tumor,including proliferation,genomic instability,aneuploid karyotype,and metastasis.In recent years,there are some studies which explore the association between AURKA and immune activity.The initial understanding of AURKA's effect on immune response came from its use in immunotherapy.AURKA epitopes activate an anti-AURKA immune response that kills tumor cells with high level of AURKA.In addition,It has been found that AURKA inhibition can directly interfere with immune response by inducing cell transformation,T cell activation and immune cell infiltration.This review summarized these findings of AURKA involvement in immune regulation.