摘要
自噬是真核生物中一种进化保守的溶酶体或液泡依赖的分解代谢途径。自噬可被分为选择性自噬和非选择性自噬。细胞通过双层或多层膜包裹待降解产物形成自噬体,然后将其运送至溶酶体形成自噬溶酶体降解细胞内物质,自噬有利于维持细胞的代谢平衡,是一种细胞自我保护机制。在营养缺乏时自噬被诱导,能够促进营养物质和代谢产物的利用,在细胞代谢调控中起着重要的作用,而细胞的代谢状态反过来又影响着自噬。该篇综述概述了不同类型的自噬所发挥的功能,包括脂自噬、铁蛋白自噬、糖自噬、聚合物自噬、线粒体自噬、过氧化物酶体自噬、内质网自噬和核糖体自噬。
Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic pathway in eukaryotes.Autophagy can be either selective or non-selective.Cells form autophagosomes by encapsulating the degraded products with double or multi-layer membrane,and then transport them to lysosomes to form autophagy-lysosomes and degrade cytotosolic substances by various enzymes.Autophagy contributes to maintaining the metabolic balance of cells,which is a mechanism of cell self-protection.Autophagy can be induced during nutritional deficiency,and can promote the utilization of nutrients and metabolites.It plays a vital role in the regulation of cell metabolism.Meanwhile,the metabolic status of cells affects autophagy in turn.In this review,the functions of different exceutive types of autophagy were summarized,including lipophagy,ferritinophagy,glycophagy,aggrephagy,mitophagy,pexophagy,reticulophagy and ribophagy.
作者
杜灿灿
刘丽姗
李文静
马慧丽
李艳花
洪薇
邓一鸣
张朝阳
于莉莉
DU Cancan;LIU Lishan;LI Wenjing;MA Huili;LI Yanhua;HONG Wei;DENG Yiming;ZHANG Chaoyang;YU Lili(Department of Immnunolgy,School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China;Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy,Xinxiang 453003,China;Institute of Precision Medicine,Xinxiang Medical University,Xinxiang 453003,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第11期2003-2013,共11页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81500675、82070895)
2018年大学生创新创业训练计划项目
2020年大学生创新创业训练计划项目(批准号:S202010472059)资助的课题。
关键词
自噬
大自噬
微自噬
线粒体自噬
代谢平衡
autophagy
macroautophagy
microautophagy
mitophagy
metabolic balance