摘要
骨肉瘤是常见的骨恶性肿瘤,其高复发、高转移率及化疗耐药等问题增加了骨肉瘤的治疗难度。m6A甲基化是哺乳动物中最常见的RNA修饰,在不改变碱基序列的情况下调控基因转录后的表达。它主要通过甲基化转移酶、甲基化阅读蛋白、去甲基化酶这三类蛋白参与许多生物学过程和疾病的发生。目前已证实,多种基因的m6A甲基化与骨肉瘤的发生、发展密切相关。该文就m6A甲基化与骨肉瘤关系的研究进行综述,旨在为骨肉瘤的治疗提供新方向。
Osteosarcoma is a common malignant bone tumor.The problems of high recurrence,high metastasis rate and chemotherapy resistance make the treatment of osteosarcoma more difficult.m6A methylation is the most common RNA modification in mammals,regulating the post-transcriptional expression of genes without changing the base sequence.It mainly participates in many biological processes and diseases through the three types of proteins:methyltransferase,methylated reading protein,and demethylase.It has been confirmed that m6A methylation of multiple genes is closely related to the occurrence and development of osteosarcoma.Therefore,this article reviews the researches on the relationship between m6A methylation and osteosarcoma,and aims to provide a new direction for the potential targeted therapy of osteosarcoma.
作者
黄媚
陈熙
邹军
HUANG Mei;CHEN Xi;ZOU Jun(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;School of Sports Science,Wenzhou Medical University,Wenzhou 325035,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第11期2045-2051,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81702235、81871835)
上海市人类运动能力开发与保障重点实验室(上海体育学院)资助项目(批准号:11DZ2261100)资助的课题。
关键词
m6A甲基化
骨肉瘤
调控
m6A methylation
osteosarcoma
regulation
