蛋白质棕榈酰化在癌症中的研究进展

Research Progress of Protein Palmitoylation in Cancer

棕榈酰化是可逆的蛋白质翻译后修饰,对蛋白质的定位、扩散和稳定性的动态调控至关重要。ZDHHC棕榈酰基转移酶家族是负责棕榈酰化的主要成员。多种癌细胞的增殖、迁移和侵袭都依赖于癌症相关蛋白的棕榈酰化。人类ZDHHC家族的23个成员多数都参与肿瘤的调节,使得靶向ZDHHC成为潜在的肿瘤治疗策略。该文主要综述了ZDHHC对不同癌症相关蛋白的棕榈酰化在癌症进程中的研究进展,讨论了靶向此途径在癌症治疗中的应用潜力。

Palmitoylation is a reversible posttranslational modification of proteins,which has a prominent role in dynamic regulating protein location,trafficking and stability.Palmitoylation of proteins are mainly catalyzed by ZDHHC palmitoyltransferase.ZDHHC-mediated palmitoylation of cancer-related protein is essential for cancer cell proliferation,migration and invasion.Most of the 23 members of human ZDHHC family involved in regulation of tumor development,raising the possibility of therapeutic strategies targeting this modification process.Here the research progress of ZDHHC-mediated palmitoylation in different cancers was reviewed and the potential of targeting this pathway in cancer treatment was also discussed.