硫酸镁联合硝苯地平在子痫前期治疗中的价值及对胎盘血流动力学指标、炎性指标的影响

The Value of Magnesium Sulfate Combined with Nifedipine in Treatment of Preeclampsia and Its Effect on the Indexes of Placental Hemodynamics and Inflammation

目的:研究硫酸镁联合硝苯地平在子痫前期治疗中的价值及对胎盘血流动力学指标、炎性指标的影响。方法:回顾性分析2017年1月-2019年6月笔者所在医院收治的80例子痫前期患者的临床资料,根据用药不同分为硫酸镁组和联合治疗组,各40例。硫酸镁组进行硫酸镁治疗,联合治疗组进行硫酸镁联合硝苯地平治疗。比较两组治疗效果,治疗前后血压、胎盘血流动力学指标、炎性指标,围生期不良事件发生情况。结果:联合治疗组治疗总有效率为90.00%,高于硫酸镁组的72.50%,差异有统计学意义(P<0.05)。治疗后,两组舒张压、收缩压、Hcy、CRP、RI、PI、S/D水平均低于治疗前,且联合治疗组舒张压、收缩压、Hcy、CRP、RI、PI、S/D水平均低于硫酸镁组,差异均有统计学意义(P<0.05)。联合治疗组围生期不良事件发生率为7.50%,低于硫酸镁组的25.00%,差异有统计学意义(P<0.05)。结论:硫酸镁联合硝苯地平在子痫前期治疗中的效果更好,可有效改善患者血压水平、胎盘血流动力学指标、炎性指标,围生期不良事件发生率更低,值得临床推广应用。

Objective:To study the value of Magnesium Sulfate combined with Nifedipine in treatment of preeclampsia and its effect on the indexes of placental hemodynamics and inflammation.Method:The clinical datas of 80 patients with preeclampsia in our hospital from January 2017 to June 2019 were analyzed retrospectively.According to different drugs,the patients were divided into the Magnesium Sulfate group and combined treatment group,with 40 cases in each group.The Magnesium Sulfate group was treated with Magnesium Sulfate,and the combined treatment group was treated with Magnesium Sulfate and Nifedipine.The therapeutic effect,blood pressure,placental hemodynamic index,inflammatory index before and after treatment and adverse events in perinatal period were compared.Result:The total effective rate of the combined treatment group was 90.00%,higher than 72.50%in the Magnesium Sulfate group,the difference was statistically significant(P<0.05).After treatment,the levels of DBP,SBP,Hcy,CRP,RI,PI,S/D in the two groups were were lower than those before treatment,and DBP,SBP,Hcy,CRP,RI,PI,S/D in the combined treatment group were lower than those in the Magnesium Sulfate group,the differences were statistically significant(P<0.05).The incidence of perinatal adverse events in the combined treatment group was 7.50%,lower than 25.00%in the Magnesium Sulfate group,the difference was statistically significant(P<0.05).Conclusion:Magnesium Sulfate combined with Nifedipine is more effective in the treatment of preeclampsia.It can effectively improve the blood pressure level,placental hemodynamic index and inflammatory index level of patients.The incidence of adverse events in perinatal period is lower,which is worthy of clinical application.