四种常见肾病综合征的临床资料分析

Clinical differences of four common nephrotic syndrome

目的:探讨局灶节段性肾小球硬化(FSGS)、系膜增生性肾小球肾炎(MsPGN)、微小病变肾病(MCD)及膜性肾病(MN)的临床特征。方法:收集于某院治疗的四组患者149例,回顾性分析比较临床指标差异。结果:MsPGN组高血压比例高于MCD、MN组,肾病综合征比例较低;与FSGS组相比,MCD组血白蛋白较高,胆固醇较低,MN组血红蛋白较低;MsPGN组舒张压高于MCD组,血胆固醇低于MCD、MN组,血白蛋白高于其他三组,24 h尿蛋白定量低于其他三组(P<0.05)。结论:FSGS、MsPGN、MCD、MN存在一定临床差异,临床医生应对其鉴别以更好地进行临床诊疗。

Objective:To compare the clinical features of mesangial proliferative glomerulonephritis(MsPGN),focal segmental glomerulosclerosis(FSGS),minimal change disease(MCD)and membranous nephropathy(MN).Methods:We retrospectively analyzed the clinical differences of 149 patients from four groups treated in hospital.Results:Compared with MCD group and MN group,the proportion of hypertension was higher and the proportion of nephrotic syndrome was lower in MsPGN group;Compared to FSGS group,MCD group had higher blood albumin and lower cholesterol,MN group had lower hemoglobin;In MsPGN group,diastolic blood pressure was higher than MCD group,blood cholesterol was lower than MCD group and MN group,blood albumin was higher and 24-hour urinary protein volume was lower than other three groups(P<0.05).Conclusion:MsPGN,FSGS,MCD and MN exit clinical differences,clinicians should distinguish them to make better clinical diagnosis and treatment.