慢性肾脏疾病中免疫功能障碍的研究进展

Research progress of immune dysfunction in chronic kidney disease

免疫系统与肾脏的关系密不可分。肾脏有助于维持机体的免疫稳态,而免疫系统的组成部分介导着多种肾脏疾病,并在慢性肾脏疾病的进展中起着核心作用。本研究总结了慢性肾脏疾病(CKD)中免疫功能障碍的相关机制,这些机制增加了CKD对感染的易感性,从而为CKD的治疗提供思路。

The relationship between the immune system and the kidney is inseparable.The kidney helps to maintain the body's immune homeostasis,and the components of the immune system mediate a variety of kidney diseases and play a central role in the progression of chronic kidney disease(CKD).In this review,we discuss the related mechanism of immune dysfunction in CKD,which increase the susceptibility of CKD to infection and offer clues to treatment of CKD.