连葛胶囊联合缬沙坦治疗肝火亢盛型围绝经期高血压病临床研究

Clinical Study of Liange Capsule(连葛胶囊)Combined with Valsartan in Treating Perimenopausal Hypertension of Hyperactive Liver Fire Syndrome

目的:观察连葛胶囊联合缬沙坦治疗肝火亢盛型围绝经期高血压病的临床疗效及安全性。方法:选取肝火亢盛型围绝经期高血压病患者180例,按随机数字表法分为治疗组和对照组各90例。对照组给予缬沙坦治疗,治疗组在对照组的基础上加用连葛胶囊,两组均连续治疗8周。比较两组患者治疗前后的血压水平及降压疗效、Kupperman评分、血清性激素水平、血脂水平、凝血功能指标水平、中医临床证候评分。结果:①治疗后,治疗组患者的血压水平、Kupperman评分、血清性激素水平、血脂水平、凝血功能指标水平、中医临床证候评分较治疗前均明显改善,差异有统计学意义(P<0.05);对照组上述指标与治疗前比较,差异无统计学意义(P>0.05)。②治疗后,治疗组患者血压水平及降压疗效、Kupperman评分、血清性激素水平、血脂水平、中医临床证候评分均优于对照组,差异有统计学意义(P<0.05)。结论:连葛胶囊对肝火亢盛型围绝经期高血压病患者不仅具有良好的降压效果,还可改善患者的中医证候和围绝经期症状,且具有良好的安全性。

Objective:To evaluate the clinical efficacy and safety of Liange Capsule(连葛胶囊)combined with valsartan in treating perimenopausal hypertension of hyperactive liver fire syndrome.Methods:A total of 180 patients with perimenopausal hypertension of hyperactive liver fire syndrome were divided into treatment group and control group by the random number table method,with 90 cases in each group.The control group was treated with valsartan,while the treatment group was treated with Liange Capsule based on the control group’s treatment.Both groups were treated for 8 weeks.Before and after treatment,the blood pressure level,antihypertensive efficacy,Kupperman score,serum sex hormone level,blood lipid level,coagulation function indicators level and traditional Chinese medicine(TCM)clinical syndrome score of the two groups were observed and recorded.Results:①After treatment,the blood pressure level,Kupperman score,serum sex hormone level,blood lipid level,coagulation function indicators level and TCM clinical syndrome score of the treatment group were significantly improved compared with those before treatment,and the difference was statistically significant(P<0.05).The differences of the above indicators in the control group between before treatment and after treatment were not statistically significant(P>0.05).②After treatment,the blood pressure level,antihypertensive efficacy,Kupperman score,serum sex hormone level,blood lipid level and TCM clinical syndrome score of the treatment group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusions:Liange Capsule not only has a good antihypertensive efficacy on perimenopausal hypertension of hyperactive liver fire syndrome,but also can improve the TCM symptoms and perimenopausal symptoms of the patients,with sound safety.