儿童过敏性结膜炎与血清维生素D3水平相关性研究

Correlation study between allergic conjunctivitis and serum vitamin D3 level in children

目的:测量儿童过敏性结膜炎患者与健康儿童血清维生素D3水平,对比分析儿童过敏性结膜炎治疗前后维生素D3水平变化,为维生素D3作为辅助药物治疗儿童过敏性结膜炎提供理论依据。方法:实验组:50例患儿经裂隙灯检查;血清IgE测定明确诊断为过敏性结膜炎。对照组:50例健康儿童经裂隙灯检查;血清IgE测定均为正常。实验组及对照组患儿年龄均为4~12岁。两组均进行血清25-羟维生素D3水平检测。实验组患儿给予抗组胺药物、拮抗白三稀药物及局部滴用抗组胺药物治疗,部分严重患者短期局部加用类固醇激素滴眼液(氟米龙滴眼液),3个月后,再次进行维生素D3水平检测。比较治疗前后血清维生素D3水平的变化有无统计学意义。结果:实验组血清25-羟维生素D3水平均明显低于对照组。实验组治疗后血清维生素D3水平较治疗前有增高(P<0.05)。结论:儿童过敏性结膜炎与血清维生素D3水平呈负相关性。

Objective:To investigate the correlation between allergic conjunctivitis and serum vitamin D3 levels in children,and to provide evidence for the supplemental treatment of allergic conjunctivitis in children with vitamin D3.Methods:Fifty children with confirmed diagnosis of allergic conjunctivitis by SLIT lamp examination and serum IgE determination were selected as the experimental group,and 50 healthy children with normal serum IgE and SLIT lamp examination were selected as the control group.The age range of the two groups was 4~12 years old,and the serum 25-Dihydroxyvitamin D3 level of the two groups was detected at the inclusion time.Children in the experimental group were given antihistamine drugs,antagonistic white powder drugs and local antihistamine drug drops.Some severe patients were given short-term local steroid hormone eye drops(Flumilone eye drops).After 3 months of treatment,vitamin D3 levels were tested again.The changes of serum vitamin D3 levels before and after treatment were compared between the experimental group and the control group.Results:The serum 25-Dihydroxyvitamin D3 level of experimental group was significantly lower than that of control group before and after treatment.The serum vitamin D3 levels of the experimental group were higher after treatment than before.There were statistically significant differences between and among groups(P<0.05).Conclusion:There was a negative correlation between serum 25-Dihydroxyvitamin D3 level and allergic conjunctivitis in children.