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癌组织标本PMS2蛋白表达与前列腺癌患者Gleasom分级关联性分析

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摘要 目的:研究癌组织标本PMS2蛋白表达与前列腺癌患者Gleasom分级的相关性。方法:选取我院2018-04~2019-04前列腺癌患者104例,取其前列腺癌组织及其癌旁组织,制作标本,观察两个标本中PMS2蛋白表达情况,并分析前列腺癌组织PMS2蛋白阳性表达与Gleasom分级的关联性。结果:前列腺癌组织中PMS2蛋白阳性表达71.15%,阴性表达28.85%;前列腺癌组织PMS2蛋白阳性表达率71.15%高于癌旁组织36.54%(P<0.05);前列腺癌组织中PMS2蛋白阳性表达与年龄、Gleasom分级、血清前列腺特异性抗原(PSA)水平、TNM分期、远处转移有关(P<0.05)。结论:前列腺癌组织PMS2蛋白阳性表达率较癌旁组织高,且与年龄、Gleasom分级、PSA水平、TNM分期、远处转移均有关,可指导临床治疗方案的确定。
作者 陈大伟
出处 《黑龙江医药科学》 2020年第6期171-172,共2页 Heilongjiang Medicine and Pharmacy
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