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猪支原体对枝原净和泰农的药物敏感性分析

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摘要 猪支原体病是造成国内外养猪业严重经济损失的重要疾病之一,抗菌药物是临床治疗猪支原体感染最快速、有效的手段。本研究以会严重危害猪群健康的猪肺炎支原体(10株)、猪鼻支原体(10株)和猪滑液支原体(1株)作为支原体的代表,采用微量肉汤稀释法测定这些支原体对临床常用抗支原体药物(枝原净和泰农)的敏感性。结果显示猪肺炎支原体对枝原净的敏感性范围为0.015μg/mL^0.25μg/mL,对泰农的敏感性介于0.03μg/mL^0.06μg/mL;猪鼻支原体对枝原净的敏感性范围为0.03μg/mL^0.5μg/mL,对泰农的敏感性为0.06μg/mL^128μg/mL;枝原净对猪滑液支原体标准株的最小抑菌浓度(Minimum Inhibitory Concentration,MIC)为0.03μg/mL,对泰农的MIC为0.25μg/mL。本研究结果有助于了解当前支原体的临床耐药情况,为猪支原体病的防控以及制定合理的抗菌药物治疗方案提供科学依据。
出处 《国外畜牧学(猪与禽)》 2020年第12期25-30,共6页 Animal Science Abroad-Pigs and Poultry
基金 江苏省自然科学基金资助项目(BK20190261)。
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