妊娠晚期孕妇抑郁情绪对新生儿神经行为发育的影响

The Effect of Depression on Neurobehavioral Development of Newborns in Late Pregnancy

目的探讨妊娠晚期孕妇抑郁情绪对新生儿神经行为发育的影响。方法选取2017年1月—2018年12月,收治本院的160例妊娠晚期孕妇抑郁情绪患者一般临床资料,妊娠周期28周以上,对孕妇抑郁情绪进行统计采用爱丁堡抑郁自评量表、负性认知加工偏向量表,对新生儿神经行为进行评估时按照婴儿神经国际量表。结果160例妊娠晚期孕妇抑郁情绪患者中,阳性30例、阴性130例,与阴性妊娠妇女相比,抑郁阳性妊娠妇女负性沉思偏向、负性解释偏向、负性记忆偏向、负性注意偏向均显著较高,差异具有统计学意义(P<0.05)。160例新生儿中,婴儿神经国际量表评分处于临界值为60例,正常值为100例,神经行为异常发生率为37.50%,负性沉思偏向、负性注意偏向与婴儿神经国际临界值呈负相关关系(P<0.05);与抑郁自评量表无明显相关性(P>0.05)。结论妊娠晚期孕妇具有较高抑郁发生率,其中负性认知加工偏向中负性沉思偏向、负性注意偏向与新生儿神经行为发育具有明显相关性。

Objective To explore the effect of depression on neurobehavioral development of newborns in late pregnancy.Method From January 2017 to December 2018,general clinical data of 160 pregnant women with depression in late pregnancy admitted to our hospital,with gestational period of more than 28 weeks.The depression of pregnant women was statistically assessed with Edinburgh Depression self-assessment scale and negative cognitive processing bias scale,and the newborn neurobehavior was assessed according to the international infant neurology scale.Results Compared with the negative pregnant women,the negative meditation bias,negative interpretation bias,negative memory bias and negative attention bias of the positive pregnant women were significantly higher,the difference was statistically significant(P<0.05).Among 160 newborns,the score of the International Infant Neurological Scale was at the critical value of 60 cases,the normal value of 100 cases,and the incidence of neurobehavioral abnormalities was 37.50%.There was a negative correlation between negative meditation bias,negative attention bias and the international critical value of infant nerve(P<0.05);there was no significant correlation between the International Infant Neurological Scale and the self rating Depression Scale(P>0.05).Conclusion The incidence of depression was higher in the late pregnant women,among which the negative cognitive processing bias,negative meditation bias and negative attention bias were significantly related to the development of neonatal neurobehavior.