微生态制剂对肝硬化合并自发性腹膜炎患者肠屏障功能的影响

Effect of microecological preparation on intestinal barrier function in patients with cirrhosis and spontaneous peritonitis

目的探讨微生态制剂对肝硬化并自发性腹膜炎(SBP)患者肠屏障功能的影响。方法纳入我院2015年5月至2019年5月收治的肝硬化并SBP患者80例,按随机数字表法分成对照组、观察组各40例。对照组给予常规治疗,观察组在此基础上加用微生态制剂,两组疗程均为2周。比较两组临床疗效,分别在治疗前、治疗2周后采集2 mL静脉血,检测两组血清内毒素(ET)、降钙素原(PCT)、超敏C反应蛋白(CRP)、白细胞介素-6(IL-6)水平,间接反映肠屏障功能的变化。记录两组不良反应与并发症情况。结果观察组总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。两组治疗后血清ET、PCT、CRP、IL-6含量均低于治疗前,且观察组较对照组显著下降(P<0.05)。观察组不良反应率为7.50%,与对照组的5.00%比较无差异(P>0.05)。观察组并发症率为5.00%,与对照组的10.00%比较无差异(P>0.05)。结论与常规治疗相比,肝硬化并SBP患者加用微生态制剂,能提升疗效,促进患者肠屏障功能改善,临床推广价值高。

Objective To investigate the effect of microecological preparation on intestinal barrier function in patients with cirrhosis and spontaneous peritonitis(SBP).Methods A total of 80 patients with cirrhosis and SBP admitted to our hospital from May 2015 to May 2019 were divided into control group and observation group according to random number table.The control group was given routine treatment,the observation group was given microecological preparation in addition to routine treatment,and the course of treatment in both groups was 2 weeks.Clinical efficacy of the 2 groups was compared.Two ml venous blood was collected before and 2 weeks after treatment,respectively.Serum endotoxin(ET),procalcitonin(PCT),hypersensitive c-reactive protein(CRP),and interleukin-6(IL-6)levels were detected in the 2 groups,to indirectly reflect changes of intestinal barrier function.Results The total effective rate of the observation group was 95.00%,higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum ET,PCT,CRP and IL-6 in both groups were lower than those before treatment,and the levels in the observation group were significantly lower than those in the control group(P<0.05).The adverse reaction rate was 7.50%in the observation group and 5.00%in the control group,with no significant difference(P>0.05).The complication rate was 5.00%in the observation group and 10.00%in the control group,with no significant difference(P>0.05).Conclusion Compared with the conventional treatment in patients with cirrhosis and SBP,the addition of microecological agents can promote intestinal barrier function and improve the curative effect,with high value of clinical application.