泮托拉唑治疗消化性溃疡合并上消化道出血的临床研究

Clinical Study of Pantoprazole in the Treatment of Peptic Ulcer Combined with Upper Gastrointestinal Bleeding

目的研究泮托拉唑治疗消化性溃疡合并上消化道出血的临床效果。方法选取2018年7月至2020年4月贵州省天柱县人民医院收治的68例消化性溃疡合并上消化道出血患者为研究对象,按照计算机随机抽样方法分成两组,对照组(34例)予以奥美拉唑治疗,分析组(34例)予以泮托拉唑治疗。比对分析两组治疗总有效率、炎症因子、不同时段止血率及凝血功能指标。结果对照组治疗总有效率相较于分析组明显更低,差异有统计学意义(P<0.05);分析组炎症因子水平优于对照组,差异有统计学意义(P<0.05);对照组24 h止血率低于分析组,差异有统计学意义(P<0.05);对照组凝血功能指标高于分析组,差异有统计学意义(P<0.05)。结论消化性溃疡合并上消化道出血实施泮托拉唑治疗能够及时控制患者出血症状,有效改善患者炎症因子水平及凝血功能。

Objective To study the clinical effect of pantoprazole treatment for peptic ulcer combined with upper gastrointestinal bleeding.Methods Totally 68 patients with peptic ulcer complicated with upper gastrointestinal bleeding admitted to People's Hospital of Tianzhu County from July 2018 to April 2020 were selected as the research objects.According to the computer random sampling method,34 cases in the control group were treated with omeprazole,and 34 cases in the analysis group were treated with pantoprazole.The total effective rate,inflammatory factors,hemostasis rate and coagulation function indexes of the two groups were compared and analyzed.Results The total effective rate of treatment in the comparison group was significantly lower than that in the analysis group(P<0.05);the level of inflammatory factors in the analysis group was better than that in the comparison group(P<0.05);the 24 h hemostatic rate in the comparison group was lower than that in the analysis group(P<0.05);the coagulation function index of the comparison group was higher than that of the analysis group(P<0.05).Conclusion Pantoprazole treatment for peptic ulcer combined with upper gastrointestinal bleeding can control the bleeding symptoms in time and effectively improve the level of inflammatory factors and blood coagulation function in patients.