咯菌腈合成方法述评

A Review of Synthetic Methods of Fludioxonil

总结了文献报道的咯菌腈及其中间体的合成工艺路线和具体的合成方法。目前文献报道的合成方法主要有4条工艺路线,关键步骤均由2-取代-3-(2,2-二氟苯并[1,3]间二氧杂环戊烯-4-基)-肉桂腈与对甲苯磺酰甲基异腈反应制得。

The synthetic method and detailed process of fludioxonil and its intermediates reported in the literature were summarized. There were four different process routes to synthesize fludioxonil. Itwas prepared by reaction of 2-substituted3-(2, 2-difluorobenzo[d]-[1, 3]-dioxol-4-yl)-cinnamonitrileswith(4-methylphenylsulfonyl)methyl isocyanide.