25-羟基维生素D与脑出血的相关性研究

The relationship between 25-hydroxyvitamin D and cerebrohemorrhage

目的研究血清中25-羟基维生素D25-hydroxyvitamin D,25(OH)D水平与脑出血的相关性。方法收集111例脑出血患者和正常对照组130例,比较脑出血组和健康对照组血清25-羟基维生素D水平差异。结果脑出血常见危险因素如收缩压(SBP)、舒张压(DBP)、血糖、TG、高血压史、吸烟史、饮酒史,脑出血组明显高于对照组(P<0.05);脑出血组血清25-羟基维生素D水平(44.81±20.55 nmol/L对51.39±20.36 nmol/L,F=0.008,P=0.013)明显低于对照组,2组比较差异有统计学意义。采用二分类Logistic回归分析25-羟基维生素D与脑出血的相关性(β=0.706,OR=2.026,95%CI(0.984~4.175))。结论血清25-羟基维生素D与脑出血有一定的相关性,在脑出血的发生过程中扮演了重要的角色,可能是除高血压、糖尿病、高血脂和饮酒等之外脑出血的另一个独立危险因素。

Objective To investigate the relationship between the 25 hydroxyvitamin D and cerebral hemorrhage.Methods 111 cases of cerebral hemorrhage and 130 healthy controls were included in the study.Result There was significant differences in common risk factors of cerebral hemorrhage between the two groups,such as systolic blood pressure,diastolic blood pressure,diabetes,TG,hypertension,drinking and smoking(P<0.05).The 25 hydroxyvitamin D level in the control group was(44.81±20.55 nmol/L VS 51.39±20.36 nmol/L,F=0.008,P=0.013)significant higher than that of the cecebral hemorrhage group(P<0.05).Binary Logistic regression analysis was used to determine the correlation between 25 hydroxyvitamin D and cerebral hemorrhage(β=0.706,OR=2.026,95%CI(0.984~4.175)).Conclusion These results suggest that the 25 hydroxyvitamin D level in serum was associated with cerebral hemorrhage,play an important role in the occurrence of cerebral hemorrhage,and maybe serve as a risk factor for cerebral hemorrhage independent of hypertension,diabetes,hyperlipodemia and drunk.