摘要
端粒缩短是骨髓衰竭性疾病的重要发病机制,以端粒为诊疗靶点可能成为骨髓衰竭性疾病的研究新方向。端粒缩短与临床常见的获得性骨髓衰竭性疾病,包括再生障碍性贫血、骨髓增生异常综合征和免疫相关性全血细胞减少症,以及部分先天性骨髓衰竭性疾病,包括先天性角化不良和范科尼贫血有关。
Telomere shortening is an important pathogenesis of bone marrow failure diseases.As a therapeutic target,telomere may become a new research direction for bone marrow failure diseases.Telomere shortening is related to clinical acquired bone marrow failure diseases,including aplastic anemia,myelodysplastic syndrome and immune mechanism related pancytopenia.The relation between telomere shortening and some inherited bone marrow failure diseases,including dyskeratosis congenita,fanconi anemia is also referred.
作者
高小燕
刘述川
GAO Xiao-yan;LIU Shu-chuan(Department of Hematology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)
出处
《基础医学与临床》
2021年第1期116-119,共4页
Basic and Clinical Medicine
基金
黑龙江省教育厅科研基金(11541227)。
