探讨不同剂量替加环素治疗泛耐药鲍曼不动杆菌重症肺炎的效果

Effect of different doses of tigecycline on severe pneumonia caused by pan-resistant Acinetobacter baumannii

目的探讨泛耐药鲍曼不动杆菌重症肺炎采用不同剂量替加环素治疗的效果。方法50例泛耐药鲍曼不动杆菌重症肺炎患者,依据替加环素剂量不同分为常规剂量组和增加剂量组,每组25例。常规剂量组患者给予常规剂量替加环素治疗,增加剂量组患者给予增加剂量替加环素治疗。比较两组患者的细菌清除情况、不良反应发生情况。结果增加剂量组患者细菌总清除率为88.0%(22/25),高于常规剂量组的64.0%(16/25),差异具有统计学意义(P<0.05)。增加剂量组患者不良反应发生率为12.0%(3/25),与常规剂量组的8.0%(2/25)比较差异无统计学意义(P>0.05)。结论泛耐药鲍曼不动杆菌重症肺炎采用增加剂量替加环素治疗的效果较常规剂量好。

Objective To discuss the effect of different doses of tigecycline on severe pneumonia caused by pan-resistant Acinetobacter baumannii.Methods A total of 50 patients with severe pneumonia caused by pan-resistant Acinetobacter baumannii were divided into conventional dose group and increased dose group according to different doses of tigecycline,with 25 cases in each group.Patients in the conventional dose group were treated with conventional dose of tigecycline,while patients in the increased dose group were treated with increased dose of tigecycline.The bacterial clearance and occurrence of adverse reactions of the two groups were compared.Results The total bacterial clearance rate of increased dose group was 88.0%(22/25),which was higher than 64.0%(16/25)of conventional dose group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of increased dose group was 12.0%(3/25),which had no statistically significant difference compared with 8.0%(2/25)of conventional dose group(P>0.05).Conclusion Increased dose tigecycline has better effect in the treatment of severe pneumonia caused by pan-resistant Acinetobacter baumannii than conventional dose tigecycline.