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右美托咪定在妇科肿瘤开腹手术全麻中的临床应用

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摘要 目的分析右美托咪定在宫颈癌、子宫内膜癌等妇科肿瘤开腹手术全身麻醉(全麻)中的临床应用效果。方法60例妇科肿瘤(宫颈癌、子宫内膜癌)患者为研究对象,按入院时间奇偶性编号随机分为对照组和试验组,每组30例。对照组实施全麻及静脉泵注0.9%生理盐水,试验组在全麻的基础上于术中给予右美托咪定麻醉。对比两组不同时间段的临床指标、术后恢复效果及不良反应发生率。结果试验组患者插管时、手术结束、拔管时、拔管后5 min的平均舒张压分别为(85.45±3.54)、(87.08±3.88)、(90.21±4.27)、(92.47±6.55)mm Hg(1 mm Hg=0.133 kPa)、心率分别为(67.45±12.27)、(66.74±13.11)、(65.87±12.18)、(71.05±10.36)次/min均低于对照组的(92.17±4.28)、(94.27±5.26)、(97.08±5.33)、(99.78±7.08)mm Hg及(87.67±11.26)、(84.45±11.08)、(82.15±12.08)、(81.24±12.06)次/min,停药后即刻、停药10、30、60 min的镇静评分均高于对照组,差异有统计学意义(P<0.05)。两组拔管时间、呼吸恢复时间、唤醒睁眼时间、定向力恢复时间比较,差异无统计学意义(P>0.05)。试验组不良反应发生率10.0%显著低于对照组的43.3%,差异有统计学意义(χ^2=8.523,P=0.004<0.05)。结论在宫颈癌、子宫内膜癌等妇科肿瘤开腹手术全麻中,右美托咪定的应用,既可减轻对患者生命体征的影响,提升患者的镇静程度,还可减少不良反应,值得临床借鉴。
作者 张旭
出处 《中国现代药物应用》 2021年第1期181-183,共3页 Chinese Journal of Modern Drug Application
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