基于金属有机骨架衍生多孔碳材料用于同时检测对乙酰氨基酚和盐酸多巴胺

Porous Carbon Material Based on Metal Organic Framework for Simultaneous Determination of Acetaminophen and Dopamine

以金属有机骨架(MOFs)作为模板,在氮气氛下对其进行热处理,合成了一种金属有机骨架衍生多孔碳材料(MOFs Pyrolysis Porous Carbon,MPPC)。通过扫描电镜(SEM)、X射线粉末衍射(XRD)、X射线光电子能谱(XPS)、拉曼光谱及N2吸附-脱附测试,对其形貌和结构进行了表征。采用滴涂法将MPPC修饰在玻碳电极(GCE)表面,制备了金属有机骨架衍生多孔碳电化学传感器(MPPC/GCE)。运用循环伏安法(CV)、差分脉冲伏安法(DPV)、交流阻抗法(EIS)研究了对乙酰氨基酚(AC)和盐酸多巴胺(DA)在该修饰电极上的电化学行为。结果表明,该电极能同时检测AC和DA,在优化条件下,AC和DA的线性检测范围分别为0.5~3.5μmol/L和11~19μmol/L,检测限分别为0.004μmol/L和0.039μmol/L。该方法电流响应大、灵敏度高、检测限低,在药品检测方面具有潜在的应用价值。

A metal organic frameworks pyrolysis porous carbon(MPPC) was synthesized via heating treatment in nitrogen atmosphere with Metal Organic Frameworks(MOFs) as template. The morphology and phase purity of MPPC were characterized by scanning electron microscopy(SEM), X-ray diffraction(XRD), X-ray photoelectron spectroscopy, Raman spectrum and N2 adsorption desorption. MPPC was directly casted onto the surface of a glassy carbon electrode to obtain a MPPC-modified electrode(MPPC/GCE). The electrochemical behaviors of acetaminophen(AC) and dopamine(DA) on MPPC/GCE were investigated with cyclic voltammetry, different pulse voltammetry and electrochemical impedance spectroscopy. The experimental results showed that MPPC/GCE exhibited exceptional catalytic ability for both AC and DA. Under the optimized experimental conditions, the linear ranges for detecting AC and DA were 0.5-3.5 μmol/L and 11-19 μmol/L, respectively. The limits of detection were 0.004 μmol/L and 0.039 μmol/L, respectively. This method was uesd for the simultaneous determination of AC and DA with strong electroactivity of redox, highly distinguishing ability and low limits of detection and showed potential application in drug detection.