基于代谢组学的锰毒性作用机制分析

Mechanism Analysis of Manganese Toxicity Based on Metabolomics

细胞的进程中有很多金属离子的参与,因此金属离子在生物系统中有着非常多且比较重要的作用。每个细胞都有一连串起着调节作用的蛋白,它们调节生物膜内外的化学物质、信号交换、细胞内络合物和其他体内基因的遗传信息合成基因产物的表达并调节金属离子稳态。检验有毒性金属离子对生物体的意义很大。微量元素锰是人体必不可少的营养素,有许多作用,如细胞脂质的抗氧化功能和能量的代谢。然而,如果人体的锰含量过多,易造成心血管、骨质疏松等不良疾病。因为其为多种致病因素且有宽泛的容易感染人群,具有神经毒性的锰一直是公众健康的重点。尽管锰在细胞调节中的作用已经被广泛研究,但在细胞水平上锰稳态的机制仍然很少涉及。本文就代谢组学的概念、研究方法及基于代谢组学的锰毒性作用机制等方面的研究进行探讨。

There are many metal ions participating in the process of cell,so metal ions play a very important role in biological system.Each cell has a series of proteins that play a regulatory role.They regulate the chemical substances and signal exchange inside and outside the biofilm,the complex in the cell and other compounds can inhibit the expression of gene products synthesized by genetic information in the body and regulate the metal ion homeostasis.The detection of toxic metal ions has a great impact on organisms.The trace element manganese is an indispensable nutrient for human body,which has many functions,such as antioxidant function of cell lipids and energy metabolism.However,if there is too much manganese in human body,it is easy to cause cardiovascular,osteoporosis and other adverse diseases.Because it's variety of pathogenic factors and a wide range of susceptible people,manganese with neurotoxicity has always been the focus of public health.Although the role of manganese in cell regulation has been extensively studied,the mechanism of manganese homeostasis at the cellular level is still rarely involved.In this paper,the concept and research methods of metabonomics and the toxic mechanism of manganese based on metabonomics were discussed.